바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.78 No.4
Citation Share

Predictors of Recurrence after Curative Resection in Patients with Early-Stage Non-Small Cell Lung Cancer

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2015, v.78 no.4, pp.341-348











& (2015). Predictors of Recurrence after Curative Resection in Patients with Early-Stage Non-Small Cell Lung Cancer. Tuberculosis & Respiratory Diseases, 78(4), 341-348.
  • Downloaded
  • Viewed
PDF Download

Abstract

Background: There have been various results from studies concerning the predictors of recurrence in early-stage nonsmallcell lung cancer (NSCLC). Therefore, an accurate assessment is needed to guide effective adjuvant therapy. Weinvestigated the predictors of a recurrence in patients with resected, early-stage NSCLC and the risk factors associatedwith locoregional or distant recurrence. Methods: This retrospective study was conducted on patients at the Pusan National University Hospital from January2006 to December 2011. Patients with pathological stages I or II were included in this study, as based on the seventhedition TNM staging system. Multivariate Cox proportional hazard models were used to identify factors associated withrecurrence. Results: Two hundred and forty-nine patients were included. Among them, 180 patients were stage I, and 69 werestage II. Overall, by multivariate analysis, the independent factors associated with a 5-year total recurrence were thepresence of visceral pleural invasion (VPI) (p=0.018) and maximal standardized uptake values (SUVs) of tumors onpositron emission tomography (PET) >4.5 (p=0.037). The VPI was the only independent risk factor associated withboth locoregional and distant recurrence, in the analysis of the patterns of tumor recurrence and their risk factors. Inthe subgroup analysis of stage I patients, three variables (male, VPI and resection margin positive) were significantlyassociated with a 5-year recurrence. Conclusion: The independent factors associated with postoperative recurrence in early-stage NSCLC were as follows:PET SUV >4.5 and the presence of VPI. For patients with those factors adjuvant therapy should be recommended as amore efficacious treatment.

keywords
Recurrence, Carcinoma, Non-Small-Cell Lung, Drug Therapy, Adjuvants

Reference

1.

1. Maeda R., Yoshida J., Ishii G., Hishida T., Nishimura M., Nagai K. (2011), Risk factors for tumor recurrence in patients with early-stage (stage I and II) non-small cell lung cancer: patient selection criteria for adjuvant chemotherapy according to the seventh edition TNM classification. Chest, 140,1494-502.

2.

2. Immerman SC., Vanecko RM., Fry WA., Head LR., Shields TW. (1981), Site of recurrence in patients with stages I and II carcinoma of the lung resected for cure. Ann Thorac Surg, 32,23-7.

3.

3. Koo HK., Jin SM., Lee CH., Lim HJ., Yim JJ., Kim YT. (2011), Factors associated with recurrence in patients with curatively resected stage I-II lung cancer. Lung Cancer, 73,222-9.

4.

4. Chen YY., Huang TW., Tsai WC., Lin LF., Cheng JB., Chang H. (2014), Risk factors of postoperative recurrences in patients with clinical stage I NSCLC. World J Surg Oncol, 12,10.

5.

5. Liu WS., Zhao LJ., Pang QS., Yuan ZY., Li B., Wang P. (2014), Prognostic value of epidermal growth factor receptor mutations in resected lung adenocarcinomas. Med Oncol, 31,771.

6.

6. Nadal E., Chen G., Prensner JR., Shiratsuchi H., Sam C., Zhao L. (2014), KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma. J Thorac Oncol, 9,1513-22.

7.

7. Higashi K., Ueda Y., Arisaka Y., Sakuma T., Nambu Y., Oguchi M. (2002), 18F-FDG uptake as a biologic prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer. J Nucl Med, 43,39-45.

8.

8. Travis WD., Brambilla E., Noguchi M., Nicholson AG., Geisinger KR., Yatabe Y. (2011), International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol, 6,244-85.

9.

9. Kelsey CR., Marks LB., Hollis D., Hubbs JL., Ready NE., D’Amico TA. (2009), Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients. Cancer, 115,5218-27.

10.

10. Hung JJ., Hsu WH., Hsieh CC., Huang BS., Huang MH., Liu JS. (2009), Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax, 64,192-6.

11.

11. Goldstraw P., Crowley J., Chansky K., Giroux DJ., Groome PA., Rami-Porta R. (2007), The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol, 2,706-14.

12.

12. Hammar SP. (1994), The pathology of benign and malignant pleural disease. Chest Surg Clin N Am, 4,405-30.

13.

13. Wang NS. (1975), The preformed stomas connecting the pleural cavity and the lymphatics in the parietal pleura. Am Rev Respir Dis, 111,12-20.

14.

14. Manac’h D., Riquet M., Medioni J., Le Pimpec-Barthes F., Dujon A., Danel C. (2001), Visceral pleura invasion by non-small cell lung cancer: an underrated bad prognostic factor. Ann Thorac Surg, 71,1088-93.

15.

15. Rami-Porta R., Ball D., Crowley J., Giroux DJ., Jett J., Travis WD. (2007), The IASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol, 2,593-602.

16.

16. Fibla JJ., Cassivi SD., Brunelli A., Decker PA., Allen MS., Darling GE. (2012), Re-evaluation of the prognostic value of visceral pleura invasion in Stage IB non-small cell lung cancer using the prospective multicenter ACOSOG Z0030 trial data set. Lung Cancer, 78,259-62.

17.

17. Lakha S., Gomez JE., Flores RM., Wisnivesky JP. (2014), Prognostic significance of visceral pleural involvement in early-stage lung cancer. Chest, 146,1619-26.

18.

18. Zhang ZJ., Chen JH., Meng L., Du JJ., Zhang L., Liu Y. (2007), 18FFDG uptake as a biologic factor predicting outcome in patients with resected non-small-cell lung cancer. Chin Med J (Engl), 120,125-31.

19.

19. Paesmans M., Berghmans T., Dusart M., Garcia C., Hossein- Foucher C., Lafitte JJ. (2010), Primary tumor standardized uptake value measured on fluorodeoxyglucose positron emission tomography is of prognostic value for survival in non-small cell lung cancer: update of a systematic review and metaanalysis by the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer Staging Project. J Thorac Oncol, 5,612-9.

20.

20. Dhital K., Saunders CA., Seed PT., O’Doherty MJ., Dussek J. (2000), [(18) F]Fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancer. Eur J Cardiothorac Surg, 18,425-8.

21.

21. Vansteenkiste JF., Stroobants SG., Dupont PJ., De Leyn PR., Verbeken EK., Deneffe GJ. (1999), Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucosepositron emission tomography scan in non-small-cell lung cancer: an analysis of 125 cases. Leuven Lung Cancer Group. J Clin Oncol, 17,3201-6.

22.

22. Keyes JW Jr. (1995), SUV: standard uptake or silly useless value?, J Nucl Med, 36,1836-9.

23.

23. de Geus-Oei LF., van Krieken JH., Aliredjo RP., Krabbe PF., Frielink C., Verhagen AF. (2007), Biological correlates of FDG uptake in non-small cell lung cancer. Lung Cancer, 55,79-87.

24.

24. Hung JJ., Yeh YC., Jeng WJ., Wu KJ., Huang BS., Wu YC. (2014), Predictive value of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma in tumor recurrence and patient survival. J Clin Oncol, 32,2357- 64.

25.

25. Sawyer TE., Bonner JA., Gould PM., Foote RL., Deschamps C., Lange CM. (1999), Factors predicting patterns of recurrence after resection of N1 non-small cell lung carcinoma. Ann Thorac Surg, 68,1171-6.

26.

26. Varlotto JM., Recht A., Flickinger JC., Medford-Davis LN., Dyer AM., Decamp MM. (2009), Factors associated with local and distant recurrence and survival in patients with resected nonsmall cell lung cancer. Cancer, 115,1059-69.

Tuberculosis & Respiratory Diseases

e-Submission OA Policy