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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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충치예방과 관련된 천연물(natural products) 연구의 현황

Natural Product Research in Dental Caries Prevention

Abstract

Dental caries is a biofilm-related oral disease, and continues to afflict the majority of the world’s population. Although fluoride, delivered in various modalities, remains the mainstay for the prevention of caries, additional approaches are required to enhance its effectiveness. Natural products have been used as a major source of innovative and effective therapeutic agents throughout human history, and have shown promise as a source of components for the development of new drugs. In addition, studies using natural products to prevent or treat oral diseases such as dental caries have received a great deal of attention. A number of compounds, such as epicatechin, allicin and sanguinarine, isolated from natural products, have also been investigated for their efficacy against oral microbial pathogens. However, the use of natural products as an anti-caries agent in clinical practice was controversial because of inadequate knowledge concerning their mechanisms of action and chemical characterization. This study focuses on the current knowledge of natural products in dental caries prevention and suggests natural products are importance sources for the prevention of dental caries.

keywords
Dental Caries, Dental biofilms, Natural Products, Virulence Factors

참고문헌

1.

1. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007; 70:461-447.

2.

2. Hirschfeld I. The Toothbrush: Its Use and Abuse. A Treatise on Preventive Dentistry and Periodontia as Related to Dental Hygiene. New York, Dental Items of Interest Publishing, 1939.

3.

3. Jagtap AG, Karkera SG. Extract of Juglandaceae regia inhibits growth, in vitro adherence, acid production and aggregation of Streptococcus mutans. J Pharm Pharmacol 2000; 52:235-242.

4.

4. Hur J. Dong-Eui-Bo-Gam vol. 6. Seoul, Yeogang Press, 1994.

5.

5. Cannell RJP. Natural products isolation. Totowa, Humana Press, 1998.

6.

6. Singer AC, Crowley DE, Thompson IP. Secondary plant metabolites in phytoremediation and biotransformation. Trends Biotechnol 2003; 21:123-130.

7.

7. Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology 2003; 149:279-.294.

8.

8. Loesche WJ. Role of Streptococcus mutans in human dental decay. Microbiol Rev 1986; 50:353-380.

9.

9. Jeon JG, Rosalen PL, Falsetta ML, Koo H. Natural products in caries research: current (limited) knowledge, challenges and future perspective. Caries Res 2011; 45:243-263.

10.

10. Pandit S, Kim HJ, Park SH, Jeon JG. Enhancement of fluoride activity against Streptococcus mutans biofilms by a substance separated from Polygonum cuspidatum. Biofouling 2012; 28:279-287.

11.

11. Jeon JG, Pandit S, Xiao J, Gregoire S, Falsetta ML, Klein MI, Koo H. Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. Int J Oral Sci. 2011; 3:98-106.

12.

12. Osawa K, Miyazaki K, Shimura S, Okuda J, Matsumoto M, Ooshima T. Identification of cariostatic substances in the cacao bean husk: their anti-glucosyltransferase and antibacterial activities. J Dent Res 2001; 80:2000-2004.

13.

13. Saeki Y, Kato T, Naito Y, Takazoe I, Okuda K. Inhibitory effects of funoran on the adherence and colonization of mutans streptococci. Caries Res 1996; 30:119-125.

14.

14. Otake S, Makimura M, Kuroki T, Nishihara Y, Hirasawa M. Anticaries effects of polyphenolic compounds from Japanese green tea. Caries Res 1991; 25:438-443.

15.

15. Shinada K, Tagashira M, Watanabe H, Sopapornamorn P, Kanayama A, Kanda T, Ikeda M, Kawaguchi Y. Hop bract polyphenols reduced three-day dental plaque regrowth. J Dent Res 2007; 86:848-851.

16.

16. Ooshima T, Minami T, Matsumoto M, Fujiwara T, Sobue S, Hamada S. Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats. Caries Res 1998; 32:75-80.

17.

17. Koo H, Schobel B, Scott-Anne K, Watson G, Bowen WH, Cury JA, Rosalen PL, Park YK. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res 2005; 84:1016-1020.

18.

18. Tarsi R, Muzzarelli RA, Guzm?n CA, Pruzzo C. Inhibition of Streptococcus mutans adsorption to hydroxyapatite by low-molecular-weight chitosans. J Dent Res 1997; 76:665-672.

19.

19. Shouji N, Takada K, Fukushima K, Hirasawa M. Anticaries effect of a component from shiitake (an edible mushroom). Caries Res 2000;34: 94-98.

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