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ISSN : 0376-4672
교정력은 치아를 움직이기 위해 가하는 힘이다. 치아가 힘을 받으면, 세포외기질(extracellular matrix)이 변형되며, 치아주위조직에 새로운 신호가전달된다. 이와 같이 외부의 힘이 세포의 신호전달로이어지는 과정을 mechanotransduction이라고 한다. 이는 치아를 움직이는 기본 전략이다. 따라서 교정 력 으 로 치 아 를 이 동 (orthodontic tooth movement; OTM)시키는 과정에 신호의 발생, 전달, 세포골격계의 재구성(cytoskeletal reorganization),유전자 발현, 세포분화, 세포증식,특수한 물질의 합성 및 분비 그리고 세포사멸(apoptosis) 등 세포수준에서 변화가 뒤따른다.
Orthodontic tooth movement is a unique process which tooth, solid material is moving into hard tissue, bone. Orthodontic force in general provides the strain to the PDL and alveolar bone, which in turn generates the interstitial fluid flow(in detail, fluid flow in PDL and canaliculi). As a results of matrix strain, periodontal ligament cells and bone cells are deformed, releasing variety of cytokines, chemokines, and growth factors. These molecules lead to the orthodontic tooth movement(OTM). In these inflammation and tissue remodeling sites, all of the cells could closely communicate with one another, flowing the information for tissue remodeling. To accelerate the rate of OTM in future, local injection of single growth factor(GF) or a combination of multiple GF's in the periodontal tissues might intervene to stimulate the rate of OTM. Corticotomy is effective and safe to accelerate OTM.
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