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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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Effect of Collagen Plug and Bone Graft on Bone Formation in Rabbit Extraction Model

Abstract

1. Purpose : This study aimed to investigate the differences in bone regeneration capacity following extraction between a control group without biomaterial placement and experimental groups where biomaterials were inserted (including xeno graft, synthetic bone-containing collagen plugs, and collagen plugs). 2. Materials and Methods : Bilateral extraction of maxillary first premolars or second premolars was performed, dividing the rabbits into four groups [① Group 1 :no bone graft or collagen plug inserted, ② Group 2: collagen plug inserted after extraction, ③ Group 3: collagen plug containing synthetic bone inserted after extraction, ④ Group 4: xenograft material inserted after extraction]. After euthanized the rabbit, Four and eight weeks postoperatively, the extent of bone formation were evaluated histologically and radiographically. 3 Results : The degree of new bone formation using histological analysis showed higher results in both the control groups at weeks 4 and 8, although not statistically significant. Across all groups, higher bone formation was observed at 8 weeks compared to 4 weeks. In radiological analysis using micro CT, Bone Mineral Density (BMD) and Bone Volume/Tissue Volume(BV/TV) were highest in Group 4. Trabecular bone thickness(Tb.Th) was highest in the control group, but not statistically significant. 4. Conclusion : In all groups, the degree of new bone formation at 4 and 8 weeks did not show statistically significant differences histologically and radiologically.

keywords
Bone graft, collagen plug, Xenograft

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