논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

정천탕의 알러지에 대한 실험적 연구

The Experimental study of Jungchun-tang on Allergies

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.3, pp.495-501
손창규 (대전대학교)
설인찬 (대전대학교)
  • 다운로드 수
  • 조회수

초록

목적 : 정천탕(定喘湯, JCT)이 IgE/mast cell로 유도되는 천식(喘息)등의 알러지성 질환에 대한 효과를 실험적으로 검증하고자 하였다.

keywords
Jungchuntang, IL-4, IL-6, anti CD40, IgE Production, Histamine, Jungchuntang, IL-4, IL-6, anti CD40, IgE Production, Histamine

Abstract

This report describes an inhibitory effect of Jungchuntang(JCT) on immediate hypersensitivity through IgE/mast cell/mediator pathaway. JCT is an Oriental herbal medication, which has been used for the treatment of allergic patients with espatially asthma in Korea. JCT significantly inhibited the IgE production in mice and IL-4 + anti CD40-mediated IgE production in vitro. JCT promoted IFN-expression but inhibited IL-4 and IL-6 mRNA expression. JCT dose-dependently inhibited the compound 48/80-induced histamine release from mast cell line, IC-2 cell. Thease results indicated that JCT has treatmentary effect on atopic disorder, such as asthma.

keywords
Jungchuntang, IL-4, IL-6, anti CD40, IgE Production, Histamine, Jungchuntang, IL-4, IL-6, anti CD40, IgE Production, Histamine


  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

대한한의학회지