- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Inhibitory Effect of Kamisopunghwalhyeol-tang (Jiaweishufenghuoxie-tang) on Inflammatory Cytokine Production and NF-kB and AP-1 Activation in Cultured Human Fibroblast-like Synoviocytes
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.3, pp.514-525
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(2003). Inhibitory Effect of Kamisopunghwalhyeol-tang (Jiaweishufenghuoxie-tang) on Inflammatory Cytokine Production and NF-kB and AP-1 Activation in Cultured Human Fibroblast-like Synoviocytes. Journal of Korean Medicine, 24(3), 514-525.
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Abstract
Objectives : This study was carried out to investigate the effects of Kami-So-Pung-Hwal-Hyeol -Tang (Kami-SPHHT) on the immunity responses of the synoviocytes isolated from the patients on rheumatoid arthritis. Methods : Cells were stimulated by Interleukin-1β and Tumor Necrosis Factor-α in the presence or absence of Kami-SPHHT, and then induced cytokine mRNA levels were determined by RT-PCR and real-time quantitative RT-PCR. Results : Levels of IL-1β, IL-6, TNF- , COX-2, and NOS II mRNA expressions were significantly decreased in Kami-SPHHT treated cells compared to non-treated control cells. Also, DNA-binding activity of NF-κB and AP-1 was decreased in Kami-SPHHT treated hFLSs. Conclusion : These results suggest that Kami-SPHHT may be involved in anti-inflammatory reactions by inducing cytokine gene expression in synoviocytes, and further in vivo examination on its efficacy can provide potential application for the treatment of rheumatoid arthritis.
- keywords
- Rheumatoid arthritis, Kami-So-Pung-Hwal-Hyeol-Tang, Human fibroblast-like synoviocytes, Inflammatory cytokine, NF-κB, AP-1, Rheumatoid arthritis, Kami-So-Pung-Hwal-Hyeol-Tang, Human fibroblast-like synoviocytes, Inflammatory cytokine, NF-κB, AP-1
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