Inhibitory Effect of Kamisopunghwalhyeol-tang (Jiaweishufenghuoxie-tang) on Inflammatory Cytokine Production and NF-kB and AP-1 Activation in Cultured Human Fibroblast-like Synoviocytes

양동원; 오민석; 김동희

ACOMS+ 및 학술지 리포지터리 설명회

한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
2024년 07월 03일(수) 13:30

사전등록 바로가기

오늘 하루 그만보기

권한신청
P-ISSN1010-0695
E-ISSN2288-3339

홈으로

전체 논문 목록

논문 상세

Home > 논문 상세

P-ISSN 1010-0695
E-ISSN 2288-3339

논문 투고

24권 3호

Inhibitory Effect of Kamisopunghwalhyeol-tang (Jiaweishufenghuoxie-tang) on Inflammatory Cytokine Production and NF-kB and AP-1 Activation in Cultured Human Fibroblast-like Synoviocytes

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339

2003, v.24 no.3, pp.514-525

양동원 (대전대학교)
오민석 (대전대학교)
김동희 (대전대학교)

양동원, 오민석, & 김동희. (2003). 加味疎風活血湯이 human fibroblast-like synoviocytes 내 염증 유발 cytokine과 전사인자에 미치는 영향. 대한한의학회지, 24(3), 514-525.

복사

다운로드 수
조회수

PDF 다운로드

Abstract

Objectives : This study was carried out to investigate the effects of Kami-So-Pung-Hwal-Hyeol -Tang (Kami-SPHHT) on the immunity responses of the synoviocytes isolated from the patients on rheumatoid arthritis. Methods : Cells were stimulated by Interleukin-1β and Tumor Necrosis Factor-α in the presence or absence of Kami-SPHHT, and then induced cytokine mRNA levels were determined by RT-PCR and real-time quantitative RT-PCR. Results : Levels of IL-1β, IL-6, TNF- , COX-2, and NOS II mRNA expressions were significantly decreased in Kami-SPHHT treated cells compared to non-treated control cells. Also, DNA-binding activity of NF-κB and AP-1 was decreased in Kami-SPHHT treated hFLSs. Conclusion : These results suggest that Kami-SPHHT may be involved in anti-inflammatory reactions by inducing cytokine gene expression in synoviocytes, and further in vivo examination on its efficacy can provide potential application for the treatment of rheumatoid arthritis.

keywords: Rheumatoid arthritis, Kami-So-Pung-Hwal-Hyeol-Tang, Human fibroblast-like synoviocytes, Inflammatory cytokine, NF-κB, AP-1, Rheumatoid arthritis, Kami-So-Pung-Hwal-Hyeol-Tang, Human fibroblast-like synoviocytes, Inflammatory cytokine, NF-κB, AP-1

다운로드 수
조회수

0KCI 피인용수
0WOS 피인용수

논문 상세

加味疎風活血湯이 human fibroblast-like synoviocytes 내 염증 유발 cytokine과 전사인자에 미치는 영향

Inhibitory Effect of Kamisopunghwalhyeol-tang (Jiaweishufenghuoxie-tang) on Inflammatory Cytokine Production and NF-kB and AP-1 Activation in Cultured Human Fibroblast-like Synoviocytes

Abstract

권호 내 다른 논문

추천 논문

권호 목록

소개

규정 및 지침

게시판

대한한의학회지