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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

5종의 한약 추출물이 함유된 헤어 에센스제품(HHRHG0202-80)이 in vitro 및 in vivo에서 육모 및 탈모 방지에 미치는 효과

The Effect of Hair Essence(HHRHG0202-80) Containing Five Herbal Extracts on Hair Growth and the Prevention of Alopecia in Vitro & Vivo

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.152-160
박원석 (태평양기술연구원)
성대석 (태평양기술연구원)
김대권 (태평양기술연구원)
조원희 (태평양기술연구원)
이해광 (태평양기술연구원)
이창훈 (동국대학교)
박성규 (경희대학교)
심영철 (태평양기술연구원)
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Abstract

Background: Androgenetic alopecia is a relatively common disorder, but its precise mechanism is not elucidated. There are two commercial drugs approved by FDA. One(finasteride) has an inhibition activity of 5α-reductase(type 2) and the other(minoxidil) has a vasodilation activity. Objectives: A verified herbal remedy for baldness is needed for medicinal treatment or preventing alopecia, which could be demonstrated by alopecia-related in vitro & in vivo tests Methods: On the basis of oriental pharmacognosy, we classified many herbal medicines into four groups (malnutrition, aging, alopecia and gray hair) according to its effect. The mitosis induction of hairy dermal papillae cell and the metabolic inhibition for type 2 5α-reductase were tested with five herbal extracts. Also, five herbal extracts were added to the normal essence formulation (HHRHG0202-80) in ranges of 0.1~0.3%, which was applied two-mouse models to validate each hair growing activity in vivo. Results: Stimulation of follicular papillae cell proliferation was observed in treatment of three herbal extracts (Glycyrrhizae radix:159.7%, Corni fructus: 144.7%, and Coicis semen: 136.6%) at a dose of 10㎍/㎖. Three herbal extracts (Biotae semen. Glycyrrhizae radix and Coicis semen) showed inhibitory activity for 5α-reductase(type 2) at 93.18%, 73.36% and 47.6%, respectively at the same dose. We observed the enhancement of hair growth activity in C57bl/6 mouse and the inhibition of alopecia in AGA mouse after topical administration of the hair essence. Conclusions: Hair essence product, which contains five medicinal plants, would be used for the remedy for male pattern baldness (MPB) and the other alopecia diseases.

keywords
Androgenetic alopecia, Hair growth, 5α-Reductase, Herbal extract, Androgenetic alopecia, Hair growth, 5α-Reductase, Herbal extract


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