- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Yeonryunggobondan and Palmijihwangtang on the Population Doubling Number and the Population Time in Rat Fibroblasts, Heart-Endothelial Cells, Messangial Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.49-59
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(2004). Effects of Yeonryunggobondan and Palmijihwangtang on the Population Doubling Number and the Population Time in Rat Fibroblasts, Heart-Endothelial Cells, Messangial Cells. Journal of Korean Medicine, 25(1), 49-59.
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Abstract
This paper is to investigate what effects Yeonryunggobondan and Palmijihwangtang have on postponing senility in rat fibroblasts, heart-endothelial cells, mesangial cells. Methods So this experimental research is focused on measuring ① the population doubling number(PDN), ② the population doubling time(PDT). 1. In vitro Yeonryunggobondan and Palmijihwangtang controlled the growth of fibroblasts, heart-endothelial cells, mesangial cells, extended the PDT of them. 2. After feeding rats the drugs for 2 months, the fibroblasts, heart-endothelial cells, mesangial cells were cultured. Results 1). In fibroblasts the PDN was incresed and the PDT was decreased at passage-1, 2 by Yeonryunggobondan and Palmijihwangtang(p＜0.05). 2). In heart-endothelial cells the PDN was incresed and the PDT was decreased at passage 8 by Yeonryunggobondan and Palmijihwangtang(p＜0.05). 3). In mesangial cells the PDN was increased and the PDT was decreased at passage 4 by Yeonryunggobondan, the PDN was incresed at passage 4 by Palmijihwangtang(p＜0.05). Conclusion It is concluded that both Yeonryunggobondan and Palmijihwangtang maybe be conductive to protect and delay the senescence of rat fibroblasts, heart-endothelial cells, mesangial cells.
- keywords
- Yeonryunggobondan, Palmijihwangtang, Fibroblasts, Heart-Endothelial Cells, Mesangial Cells, Yeonryunggobondan, Palmijihwangtang, Fibroblasts, Heart-Endothelial Cells, Mesangial Cells
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