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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Effect of Hair Essence(HHRHG0202-80) Containing Five Herbal Extracts on Hair Growth and the Prevention of Alopecia in Vitro & Vivo

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.152-160








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Abstract

Background: Androgenetic alopecia is a relatively common disorder, but its precise mechanism is not elucidated. There are two commercial drugs approved by FDA. One(finasteride) has an inhibition activity of 5α-reductase(type 2) and the other(minoxidil) has a vasodilation activity. Objectives: A verified herbal remedy for baldness is needed for medicinal treatment or preventing alopecia, which could be demonstrated by alopecia-related in vitro & in vivo tests Methods: On the basis of oriental pharmacognosy, we classified many herbal medicines into four groups (malnutrition, aging, alopecia and gray hair) according to its effect. The mitosis induction of hairy dermal papillae cell and the metabolic inhibition for type 2 5α-reductase were tested with five herbal extracts. Also, five herbal extracts were added to the normal essence formulation (HHRHG0202-80) in ranges of 0.1~0.3%, which was applied two-mouse models to validate each hair growing activity in vivo. Results: Stimulation of follicular papillae cell proliferation was observed in treatment of three herbal extracts (Glycyrrhizae radix:159.7%, Corni fructus: 144.7%, and Coicis semen: 136.6%) at a dose of 10㎍/㎖. Three herbal extracts (Biotae semen. Glycyrrhizae radix and Coicis semen) showed inhibitory activity for 5α-reductase(type 2) at 93.18%, 73.36% and 47.6%, respectively at the same dose. We observed the enhancement of hair growth activity in C57bl/6 mouse and the inhibition of alopecia in AGA mouse after topical administration of the hair essence. Conclusions: Hair essence product, which contains five medicinal plants, would be used for the remedy for male pattern baldness (MPB) and the other alopecia diseases.

keywords
Androgenetic alopecia, Hair growth, 5α-Reductase, Herbal extract, Androgenetic alopecia, Hair growth, 5α-Reductase, Herbal extract


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