논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

이전

다음

25권 1호
Share

延齡固本丹 八味地黃湯이 Rat의 피부섬유아세포,사구체 메산지움 세포 및 혈관내피세포의 老化遲延에미치는 影響

Effects of Yeonryunggobondan and Palmijihwangtang on the Population Doubling Number and the Population Time in Rat Fibroblasts, Heart-Endothelial Cells, Messangial Cells

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.49-59
박영준 (경희대학교)
안영민 (경희대학교)
안세영 (경희대학교)
두호경 (경희대학교)
박영준, 안영민, 안세영, & 두호경. (2004). 延齡固本丹 八味地黃湯이 Rat의 피부섬유아세포,사구체 메산지움 세포 및 혈관내피세포의 老化遲延에미치는 影響. 대한한의학회지, 25(1), 49-59.
  • 다운로드 수
  • 조회수

Abstract

This paper is to investigate what effects Yeonryunggobondan and Palmijihwangtang have on postponing senility in rat fibroblasts, heart-endothelial cells, mesangial cells. Methods So this experimental research is focused on measuring ① the population doubling number(PDN), ② the population doubling time(PDT). 1. In vitro Yeonryunggobondan and Palmijihwangtang controlled the growth of fibroblasts, heart-endothelial cells, mesangial cells, extended the PDT of them. 2. After feeding rats the drugs for 2 months, the fibroblasts, heart-endothelial cells, mesangial cells were cultured. Results 1). In fibroblasts the PDN was incresed and the PDT was decreased at passage-1, 2 by Yeonryunggobondan and Palmijihwangtang(p＜0.05). 2). In heart-endothelial cells the PDN was incresed and the PDT was decreased at passage 8 by Yeonryunggobondan and Palmijihwangtang(p＜0.05). 3). In mesangial cells the PDN was increased and the PDT was decreased at passage 4 by Yeonryunggobondan, the PDN was incresed at passage 4 by Palmijihwangtang(p＜0.05). Conclusion It is concluded that both Yeonryunggobondan and Palmijihwangtang maybe be conductive to protect and delay the senescence of rat fibroblasts, heart-endothelial cells, mesangial cells.

keywords
Yeonryunggobondan, Palmijihwangtang, Fibroblasts, Heart-Endothelial Cells, Mesangial Cells, Yeonryunggobondan, Palmijihwangtang, Fibroblasts, Heart-Endothelial Cells, Mesangial Cells


참고문헌

1

(1990) Induction of cellullar senescence in immortalized cells by human chromosome L,

2

(1990) Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer,

3

(1994) A gene involved in the control of cellular senescence localized to human chromosome lq,

4

(1991) Genetic analysis of indefinite division in human cells evidence for a cell senescence-related gene,

5

(1994) Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6,

6

Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibloblast cell lines KMST-6 and SUSM-1,

7

(1993) Tumor cell growth arrest caused by subchromosomeal transferable DNA fragments from chromosome 11,

8

(1991) Senescence of nikel-transformed cells by a mammalian X chromosome,

9

(1994) Evidence for Multiple Pathways to Cellular Senescence,

10

(1998) 노화지연을 위한 한약재의 효능연구 ,

11

(1998) 노인의학개론, 순천향대학교 교육매체제작센터

12

(2001) 노화현상은 비가역적인가,

  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

권호 목록

소개

규정 및 지침

게시판

대한한의학회지

  학술지 홈페이지 이용 환경은   크롬 브라우저 사용을 권장합니다.

대한한의학회지

논문 투고 OA 정책