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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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防風通聖散이 高脂肪飼料 食餌로 誘發된 肥滿생쥐에서 肥滿遺傳子 및 關聯因子에 미치는 影響

The inhibitory effects of Bangpungtongseoung-san on the obese gene and obded inhibitory about obede-mouse induced by high fat diet

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.1, pp.11-22
황상준 (대전대학교 한의과대학)
송태원 (대전대학교 한의과대학)
오민석 (대전대학교 한의과대학)
황상준, 송태원, & 오민석. (2006). 防風通聖散이 高脂肪飼料 食餌로 誘發된 肥滿생쥐에서 肥滿遺傳子 및 關聯因子에 미치는 影響. 대한한의학회지, 27(1), 11-22.
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Abstract

Object : In this study, the aim was to investigate the inhibitory effects of Bangpungtong- seoung-san on the obese gene and obese inhibitory about obese-mouse induced by high fat diet. Methods : In order to investigate the effects of Bangpungtongseoung-san(BPTS) on the obese gene and obese inhibitory, C57BL/6 mice were induced by high fat diet. C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with BPTS extract) and fed for 13weeks. Results : 1. The change of body weight and the final increase of body weight were decreased significantly. 2. The amount of the adipocyte in body weight was decreased significantly. 3. In primary adipocytes, β3AR gene expression was increased significantly and leptin gene expression was decreased in 100㎍/㎖ density significantly. 4. In primary adipocytes, the amount of TNF-α was decreased in 100 ㎍/㎖ density significantly and the amount of leptin was decreased but did not show significance. 5. In adipocytes tissue, the expression of leptin was decreased and the expression of β3AR was increased. Conclusions : These results suggest that BPTS may inhibit the expression of the obese gene and obese inhibitory about obese-mouse induced by high fat diet.

keywords
Bangpungtongseoung-san, adipocyte, obese gene, obese inhibitory., Bangpungtongseoung-san, adipocyte, obese gene, obese inhibitory.


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