- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Regulation of Interleukin-1b-induced Dedifferentiation and Apoptosis via p38 Mitogen-activated Protein Kinase pathway in Articular Chondrocytes
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.1, pp.220-228
&
(2006). Regulation of Interleukin-1b-induced Dedifferentiation and Apoptosis via p38 Mitogen-activated Protein Kinase pathway in Articular Chondrocytes. Journal of Korean Medicine, 27(1), 220-228.
- Downloaded
- Viewed
Abstract
Objective: Interleukin-1 (IL-1)b in articular chondrocytes regulates differentiation, apoptosis, and inflammatory responses. It is still controversial, So, we investigated IL-1b induces chondrocytes dedifferentiation and death. Also, we studied the role of the mitogen-activated protein kinase (MAPK) subtypes on IL-1b-induced dedifferentiation and apoptosis. Methods : To evaluation of dedifferentiation by chemokines of chondrocytes, we assessed such as proteoglycan, collagen, MMP-3 and MMP-13 by RT-PCR analysis. Also, to assess of apoptosis effect by chemokines, we measured annexin V/Propidium iodode (PI) and sub G1 cells in chondrocytes by flowcytometric analysis. Results : IL-1b treatment did not affect activation of ERK-1/2, but stimulation of p38 kinase. Inhibition of phospho ERK-1/2 with PD98059 enhanced IL-1b-induced dedifferentiation, and apoptosis up to 13.5%, whereas inhibition of phospho p38 kinase with SB203580 inhibited dedifferentiation, and apoptosis. Conclusions: Our results indicate that SB203580, p38 kinase inhibitor, inhibits IL-1b-induced dedifferentiation, and apoptosis by the inhibition of type II collagen expression and proteoglycan synthesis of rabbit articular chondrocytes.
- keywords
- Interleukin-1 (IL-1)b, chondrocytes, dedifferentiation, mitogen-activated protein kinase (MAPK), apoptosis., Interleukin-1 (IL-1)b, chondrocytes, dedifferentiation, mitogen-activated protein kinase (MAPK), apoptosis.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Combined Treatment with Oriental Herbal Medicine and Western Biomedical Medicine among Cerebrovascular Attack Patients
- The inhibitory effects of Bangpungtongseoung-san on the obese gene and obded inhibitory about obede-mouse induced by high fat diet
- Inhibitory Effects of Gaejibokryunghwan on Cell Proliferation in HeLa Cells
- Effect of Oral Sport Beverages with Medicinal Herbs Added on Short-term Recovery from Exercise-induced Fatigue
- Beneficial Effect of Epimedii Herba combined Samgijiwhang-Tang on Diabetic Nephropathy Rats
- Review of Biophoton of human beings -domestic papers
- Effects of High Frequency Herbal Medication Administrations on the Liver Functions in Rats - Focusing on Sipjeondaebo-tang, Yukmijihwang-tang, Bojungikgi -tang, and Ojeoksan-
- Effects of the Holotrichia Extract in Streptozotocin-induced Diabetic Rats
- A Study on Factors Affecting The Level of Yangseng(養生) of Certain Elderly People
- The Case-control Study of Ischemic Stroke According to Sasang Constitution
- The Study of Sasangin's Face by Sasangin Diagnosis Questionnaire (SDQ)
- The Study of Relationships between the Abdominal Fat Distribution and Sasangin
- Acupuncture on Siguan Points (LI4 and LR3) Restores Loperamide / Scopolamine-induced Intestinal Immotility in Mice
- The review of Oriental medical therapy on Allergic rhinitis
- A Study on the Variations of the Trunk Temperature and the Clinical Test for the Diabetics by the Artemisia Extract Moxibustion Method
- Anti-inflammatory effects of an ethanolic extract from Betula Platyphylla
- Establishment of Efficient Organization for Coordination Center on Clinical Research in Traditional Korean Medicine
- Development of CRF and SOPs for the Identification of Risk Factors of the Cerebrovascular Diseases in the East and West Medicine
- Regulation of Interleukin-1b-induced Dedifferentiation and Apoptosis via p38 Mitogen-activated Protein Kinase pathway in Articular Chondrocytes
- Oriental Medicine Research Center for Bone & Joint Disease
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.