- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
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The inhibitory effects of Bangpungtongseoung-san on the obese gene and obded inhibitory about obede-mouse induced by high fat diet
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.1, pp.11-22
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(2006). The inhibitory effects of Bangpungtongseoung-san on the obese gene and obded inhibitory about obede-mouse induced by high fat diet. Journal of Korean Medicine, 27(1), 11-22.
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Abstract
Object : In this study, the aim was to investigate the inhibitory effects of Bangpungtong- seoung-san on the obese gene and obese inhibitory about obese-mouse induced by high fat diet. Methods : In order to investigate the effects of Bangpungtongseoung-san(BPTS) on the obese gene and obese inhibitory, C57BL/6 mice were induced by high fat diet. C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with BPTS extract) and fed for 13weeks. Results : 1. The change of body weight and the final increase of body weight were decreased significantly. 2. The amount of the adipocyte in body weight was decreased significantly. 3. In primary adipocytes, β3AR gene expression was increased significantly and leptin gene expression was decreased in 100㎍/㎖ density significantly. 4. In primary adipocytes, the amount of TNF-α was decreased in 100 ㎍/㎖ density significantly and the amount of leptin was decreased but did not show significance. 5. In adipocytes tissue, the expression of leptin was decreased and the expression of β3AR was increased. Conclusions : These results suggest that BPTS may inhibit the expression of the obese gene and obese inhibitory about obese-mouse induced by high fat diet.
- keywords
- Bangpungtongseoung-san, adipocyte, obese gene, obese inhibitory., Bangpungtongseoung-san, adipocyte, obese gene, obese inhibitory.
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