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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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다용 한약처방투여가 흰쥐의 간기능에 미치는 영향- 십전대보탕, 육미지황탕, 보중익기탕 및 오적산을 중심으로 -

Effects of High Frequency Herbal Medication Administrations on the Liver Functions in Rats - Focusing on Sipjeondaebo-tang, Yukmijihwang-tang, Bojungikgi -tang, and Ojeoksan-

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.1, pp.78-90
한용주
이선동 (상지대학고 한의과대학)
최종환 (연세대학교)
박종구 (연세대학교)
박해모 (상지대학고 한의과대학)
장인수 (우석대학교 한의과대학)
한용주, 이선동, 최종환, 박종구, 박해모, & 장인수. (2006). 다용 한약처방투여가 흰쥐의 간기능에 미치는 영향- 십전대보탕, 육미지황탕, 보중익기탕 및 오적산을 중심으로 -. 대한한의학회지, 27(1), 78-90.
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Abstract

Background : Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well. In recent years, extensive focus was laid on adulteration of the herbal medicine with liver damage. The use of herbal preparations as remedies for various medical conditions has continuously increased in Korea. Large proportions of Korean patients use herbal medicinal products, folk remedies, and health food. However, studies on the safety of herbal products are conducted on a less than sufficient basis even in the countries like Korea where herbal medicine is being used extensively. Some of the reports on the safety of herbs were done by the doctors of western medicine but lack of knowledge and misclassification led to misunderstandings. Objectives : This study aims to verify the evidences on safety of frequently used 4 herbal medications (Sipjeondaebo-tang, Bojoongikgi-tang, Ohjeok-San, Yukmijihwang-tang) in the lab animal model. Methods : Sprague-Dawley rats was treated by 4 herbal medications during 31 days. After 1 month, we checked body weight, liver weight, and serum enzyme associated with liver function. Results : There is no significant difference in body weight and liver weight after 1 month of administrations. In all experimental groups, no abnormal findings was observed in histological research and lab liver Functions test(AST, ALT etc). Conclusions : These four herbal medications, frequently used in oriental medicine clinics and hospitals, are safe from hepatoxic events in the lab animal model.

keywords
herbal toxicity, adverse effect, hepatoxicity, liver damage, drug safety, herbal toxicity, adverse effect, hepatoxicity, liver damage, drug safety


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