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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Suppression of Cocaine Intake by Acupuncture at HT7

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2010, v.31 no.3, pp.17-27
이봉효 (대구한의대학교)
Sung-Hwan Kim (Daegu Haany University)
Sung-Chul Lim (Daegu Haany University)
김재수 (대구한의대학교)
Yun-Kyu Lee1 (Daegu Haany University)
Ji-Hye Lee (Daegu Haany University)
정태영 (대구한의대학교)
양재하 (대구한의대학교)
Seong-Shoon Yoon (Daegu Haany University)
Chang-Hyun Han (Korea Institute of Oriental Medicine)
이경민 (대구한의대학교)
이봉효, Sung-Hwan, K. , Sung-Chul, L. , 김재수, Yun-Kyu, L. , Ji-Hye, L. , 정태영, 양재하, Seong-Shoon, Y. , Chang-Hyun, H. , & 이경민. (2010). . 대한한의학회지, 31(3), 17-27.
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Abstract

Objectives: Cocaine has been well known as a representative drug of abuse for its strong reinforcing effect linked to the mesolimbic reward system including dopamine, and such reinforcement leads to the addiction. Acupuncture has been used widely in eastern Asia for the treatment of various diseases including mental disorders and psychiatric problems, and is gathering more interest as one of the complementary and alternative medicines in western countries. In a previous study, we demonstrated that acupuncture at HT7 could affect dopamine release in the mesolimbic system of rats sensitized to alcohol and morphine. This study was designed to investigate whether acupuncture at HT7 could attenuate cocaine intake or not. Material & Methods: Male Sprague-Dawley rats weighing 270-300 g at the start of experiment were trained to self-administer food pellets under a fixed ratio 1 schedule. After the success of acquisition of 100 pellets within 3 h for 3 consecutive days, animals were subjected to surgery whereby Silastic tubing was implanted into right jugular vein and secured with mesh under the anesthetization using pentobarbital injection (50 ㎎/㎏, i.p.). Following recovery, rats were trained to self-administer cocaine (0.25 ㎎/㎏) in daily 2 h sessions under fixed ratio 1 schedule over 10 days. Each treatment was performed on the next day of each establishment of baseline. Results: Results show that acupuncture at HT7, but not at control points, reduced cocaine intake significantly. Acupuncture at HT7 decreased selectively active lever response from 63.15 ± 3.35 to 51.46 ± 3.99 corresponding 82.12 ± 5.31% compared to basal level. Also, it was demonstrated that the effect of acupuncture was mainly occurred at the half period. Nevertheless, acupuncture at HT7 did not influence the food taking behavior. Conclusions: From the results of this study, it may be suggested that acupuncture at HT7, at least in part, could contribute to the treatment of cocaine abuse.

keywords
Acupuncture, HT7, Cocaine, Self-administration, Drug abuse, Rat.


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