- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
The current status of the combination therapy of frequently used herbal extracts and anti-platelet drug, anti-coagulant drug in ischemic stroke patients hospitalized in oriental medical hospital
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.2, pp.14-22
&
(2011). The current status of the combination therapy of frequently used herbal extracts and anti-platelet drug, anti-coagulant drug in ischemic stroke patients hospitalized in oriental medical hospital. Journal of Korean Medicine, 32(2), 14-22.
- Downloaded
- Viewed
Abstract
Objective: Nowadays the combined use of herbal extracts and western medicines has been prevalent, but concern about its risk is also increasing. Even though the importance of clinical trials is well recognized, there have been only a few studies on the combined use of herbal extracts and western medicines. This study was aimed to examine which herbal extracts and antiplatelets or anticoagulants are most commonly prescribed together to inpatient ischemic stroke patients and investigate the combined prescription rate. Methods: We investigated the most frequently prescribed herbal extracts from two different sources. First, we chose herbal medicine extracts from 2008 Traditional Korean Medicine Utilization Status. Then, among patients who were admitted to Kyung-Hee Oriental Medical Center diagnosed with ischemic stroke, we found patients who were administered with these herbal medicine extracts and among these patients, we investigated how many were concomitantly administered with antiplatelets or anticoagulants. Second, we chose other herbal medicine extracts that were most often prescribed within Kyung-Hee Oriental Medical Center and found patients who were administered with these herbal medicine extracts, then investigated how many of them were concomitantly administered with specific antiplatelets or anticoagulants. Results: The most commonly prescribed herbal medicine extracts among ischemic stroke patients were Ojeok-san,Bojungikgi-tang, Sochungryong-tang and Samsoeum. About 46 to 69 percent were concomitantly administered with either specific antiplatelets or anticoagulants. Conclusions: The most often prescribed herbal medicine extracts in inpatient ischemic stroke patients are Ojeok-san,Bojungikgi-tang, Sochungryong-tang, and Samsoeum. Among patients who were prescribed with Ojeok-san,Bojungikgi-tang, Sochungryong-tang, Samsoeum, patients who were concomitantly administered with either antiplatelets or anticoagulants were about 46% to 69%.
- keywords
- Herbal medicine extract, antiplatelets or anticoagulants, drug interaction, ischemic stroke, combined prescription rate
Reference
1
1. Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol. 2010;55(6):515-25.
2
2. Ernst E. Herb-drug interactions: Potentially important but woefully under-researched. Eur J Clin Pharmacol. 2000;56(8):523-4.
3
3. Fugh-Berman A, Ernst E. Herb?drug interactions: Review and assessment of report reliability. Br J Clin Pharmacol. 2001;52(5):587-95.
4
4. Engelsen J, Nielsen JD, Hansen KF. Effect of coenzyme Q10 and ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo- controlled cross-over trial. Ugeskr Laeger. 2003;165(18): 1868-71.
5
5. Savović J, Wider B, Ernst E. Effects of ginkgo biloba on blood coagulation parameters: A systematic review of randomised clinical trials. Evidence-Based Integrative Medicine. 2005;2(3): 167-76.
6
6. Eun JS. Kim DK. Song JM. The Combined Effect of Moschus and Anti-tumor drug Mitomycin C. Korean Journal of Oriental Physiology and Pathology. 2003;17(6): 1004-8.
7
7. Oh JJ. Won JH. Lee UJ. Moon SJ. Effects of Paljintanggagambang extract on antitumoral immunological response and the side effect induced by antitumoral agents. Korean J.Orient. Int.Med. 1998;19(2):219-32.
8
8. Lee SW, Park SW, Lee HC, Ko CN, Yun SW, Han JY. The effects of Constant Use of Herbal Medicine with Western Medicine On Liver and Kidney Functions. Korean J.Orient.Int.Med. 2003; 24(1):68-74.
9
9. Kwon OH, Ryu KW, Ryu BH, Yoon SH, Paek TH. Protective and healing effects of both Jiguyangwi-tang and Gamijiguyangwi-tang on gastric mucosa injuries induced by cyclophosphamide in mice. J Korean Oriental Med. 2001;22:84-93.
10
10. Kim TS. Kim CY. Min JY. Choi YG. Kang DH. The Effects of Use of Sasang-Bang with Western Medicine on Liver and Kidney Function. The Society of Sasang Constitutional Medicine. 2004; 16(3):70-5.
11
11. Shin HT, Lee SD. Effects of kidney function in blood of drug users(herbal and western) in koreans. The Korean Society For Oriental Preventive Medicine. 2004;8(2):157.
12
12. 통계청. 2002년 연간사망 통계보고서. 2004.
13
13. 한국한의학연구원. 2008년 한방 의료 이용 실태 조 사. 보건복지가족부. 2008;11-1351000-000223-01: 314-6.
14
14. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M et al. Trends in alternative medicine use in the united states, 1990-1997: Results of a follow-up national survey. JAMA. 1998;280(18):1569-75.
15
15. 한국한의학연구원. 일본한방의약품이용실태. 2009; 8:5.
16
16. Saw JT, Bahari MB, Ang HH, Lim YH. Potential drug-herb interaction with antiplatelet/anticoagulant drugs. Complement Ther Clin Pract. 2006;12(4): 236-41.
17
17. Park JK, Yoo JS, Koh KW, Kim CB, Choi SY. The Combined Treatment with Oriental Herbal Medicine and Western Biomedical Medicine among Cerebrovascular Attack Patients. J Korean Oriental Med. 2006;27(1):1-10
18
18. Antiplatelet Trialists Collaboration. Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ. 1994;308:81-106.
19
19. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2000;343(25):1833-8.
20
20. Aggarwal A, Ades PA. Interactions of herbal remedies with prescription cardiovascular medications. Coron Artery Dis. 2001;12(7): 581-4.
21
21. Watson R, Woodman R, Lockette W. Ephedra alkaloids inhibit platelet aggregation. Blood Coagul Fibrinolysis. 2010;21(3):266-71.
22
22. Holbrook AM, Pereira JA, Labiris R, McDonald H, Douketis JD, Crowther M et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005;165(10): 1095-106.
23
23. Yuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S et al. Brief communication: American ginseng reduces warfarin’s effect in healthy patients: A randomized, controlled trial. Ann Intern Med. 2004;141(1):23-7.
24
24. Lee SH, Kim YS, Kang CH, Song MG. Doo HK, Ahn SY et al. A Retrospective Sectional Study about the Effect of the Interaction of Herbal Medicines and Warfarin on Prothrombin Time (INR) in Stroke Patients. Korean J.Orient.Int. Med. 2007;28(3):464-72.
25
25. 尹吉榮. 동의임상방제학. 서울: 明寶出版社. 1985: 49-52
26
26. Kim KW, Han SH, Jung BJ, Woo SH, Kim BC, Kim YH. A case report of diabetic hyperlipidemia in a patient with cerebral infarction treated with Ojeok-san. Korean J.Orient.Int.Med. 2005;26(1): 275-80.
27
27. 허준. 동의보감. 서울:동의보감출판사. 2005:734-1073.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The anti-inflammatory effects of Huang-Lyun (Coptidis Rhizoma, CR) on injured tissue after burn elicitation
- The current status of the combination therapy of frequently used herbal extracts and anti-platelet drug, anti-coagulant drug in ischemic stroke patients hospitalized in oriental medical hospital
- Current State of Pain Treatment in Oriental Medicine
- Pattern Identification of 97 Functional Dyspepsia Patients and the Characteristics of Each Pattern Type
- Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury
- Study of Medical Devices in Traditional Korean Medical Clinics
- An Analysis of Effects on Vision Care Program Including Traditional Korean Treatment for Elementary School Students
- A Comparative Study of Pyeongwi-san, Ijin-tang and Pyeongjintang Extracts on Indomethacin-Induced Gastric Mucosal Lesions in Mice
- Case of Multiple Systemic Atrophy Treated with Korean Medical Treatment and Rehabilitation Therapy
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.