- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.2, pp.63-78
&
(2011). Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury. Journal of Korean Medicine, 32(2), 63-78.
- Downloaded
- Viewed
Abstract
Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model. Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-αand IL-1β in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin,collagen, and caspase 3, and protein level of Cdc2 in lung tissue. Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.
- keywords
- Maekmundong-tang (Maimendong-tang), chronic obstructive pulmonary disease, A549 cell, elastase
Reference
1
1. GOLD. Global strategy for th diagnosis, management, and prevention of chronic obstructive pulmonary disease(updated 2008). 2008.
2
2. Yoo CG. Pathogenesis and pathophysiology of COPD. Kor J Int Med. 2009;77:383-400.
3
3. Korea National Statistical Office, Republic of Korea [Internet]. Dajeon: Korea National Statistical Office; c1996-[cited 2008 Mar]. Available from: http://www.nso.go.kr.
4
4. NHLBI. NHLBI morbidity and mortality chartbook, [cited 2005 Feb] 2004. Available from: http://www.nhlbi.nih.gov/resources/docs/ cht-book.htm.
5
5. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997; 349:1498-504.
6
6. American Thoracic Society. Chronic bronchitis, asthma and pulmonary emphysema: a statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases. Am Rev Respir Dis 1962;85:762-8.
7
7. Gottlieb DJ, Stone PJ, Sparrow D, Gale ME, Weiss ST, Snider GL et al. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. Am J Respir Crit Care Med. 1996;154: 1290-5.
8
8. Harel S, Janoff A, Yu SY, Hurewitz A, Bergofsky EH. Desmosine radioimmunoassay for measuring elastin degradation in vivo. Am Rev Respir Dis. 1980;122:769-73.
9
9. Cantin A, Crystal RG. Oxidants, antioxidants and the pathogenesis of emphysema. Eur J Respir Dis Suppl. 1985;139:7-17.
10
10. Laurent P, Janoff A, Kagan HM. Cigarette smoke blocks cross-linking of elastin in vitro. Am Rev Respir Dis. 1983;127:189-92.
11
11. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med. 2001;163:737-44.
12
12. Tuder RM, Petrache I, Elias JA, Voelkel NF, Henson PM. Apoptosis and emphysema:the missing link. Am J Respir Cell Mol Biol. 2003;28:551-4.
13
13. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000; 106:1311-9.
14
14. 장기. 金匱要略. 북경, 인민위생출판사. 1998: 192-3.
15
15. 허준. 東醫寶鑑. 서울: 남산당. 1986:477.
16
16. Cheon MS, Chun JM, Yoon T, Lee A, Moon BC, Choo BK et al. Anti-carcinogenetic and Antimetastatic Effects of Extract from Maekmoondongtang in HepG2 Cells. Kor J Herbology. 2009; 24(3):161-7.
17
17. Kim H, Jeong HS, Kwon J, Lee KG. Effect of Maekmoondong-tang on the immunomodulatory action. Kor J Orient Physiol & Pathol. 2003; 17(4):946-51.
18
18. 정호롱, 김영신, 임윤택, 이응세. 맥문동과 맥문 동탕 투여가 심폐기능 및 피로회복효과에 미치는 영향. 대한스포츠한의학회지 2003;4(1):122-34.
19
19. Kim JJ, Jung HJ, Jung SK, Rhee HK. The effects of Maekmoondong-tang and Jeongcheonhwadamgangki- tang on immune cell and serum OAspecific IgE in BALF in rat asthma model. J Kor Orient Med. 2002;23(1):37-49.
20
20. 전국한의과대학 폐계내과학교실. 동의폐계내과 학. 서울: 한문화사. 2002:335-46.
21
21. 전국한의과대학 본초학교실. 本草學. 서울: 영림 사. 1994:121-622.
22
22. 高本釗. 신편중약대사전 (하). 臺北: 신문풍출판 공사. 1983:4277.
23
23. Nakajoh M, Fukushima T, Suzuki T, Yamaya M, Nakayama K, Sekizawa K et al. Retinoic acid inhibits elastase-induced injury in human lung epithelial cell lines. Am J Respir Cell Mol Biol. 2003;28:296-304.
24
24. Gottlieb DJ, Stone PJ, Sparrow D, Gale ME, Weiss ST, Snider GL et al. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. Am J Respir Crit Care Med. 1996; 154:1290-5.
25
25. Harel S, Janoff A, Yu SY, Hurewitz A, Bergofsky EH. Desmosine radioimmunoassay for measuring elastin degradation in vivo. Am Rev Respir Dis. 1980;122:769-73.
26
26. Foronjy R, D’Armiento J. The role of collagenase in emphysema. Respir Res. 2001;2:348-52.
27
27. Yoon JM, Park YC. Protective effects of Seonpyejeongceon-tang on elastase-induced lung injury in mice. J Kor Orient Int Med. 2010; 31(1):84-101.
28
28. Uhal BD. Cell cycle kinetics in the alveolar epithelium. Am J Physiol. 1997;272:L1031-45.
29
29. Draetta G, Beach D. The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl. 1989;12:21-7.
30
30. Draetta G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci. 1990;15:378-83.
31
31. Moreno S, Nurse P. Substrates for p34cdc2: in vivo veritas? Cell. 1990;61:549-51.
32
32. Nigg EA. The substrates of the cdc2 kinase. Semin Cell Biol. 1991;2:261-70.
33
33. Nigg EA, Krek W, Peter M. Vertebrate cdc2 kinase: its regulation by phosphorylation and its mitotic targets. Cold Spring Harb Symp Quant Biol. 1991;56:539-47.
34
34. Enoch T, Nurse P. Coupling M phase and S phase: controls maintaining the dependence of mitosis on chromosome replication. Cell. 1991; 65:921-3.
35
35. Segal RA, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci. 1996;19:463-89.
36
36. Magnuson NS, Beck T, Vahidi H, Hahn H, Smola U, Rapp UR. The Raf-1 serine/threonine kinase. Semin Cancer Biol 1994;5:247-53.
37
37. Yoon S, Seger R. The extracellular signalregulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors. 2006; 24:21-44.
38
38. Park WY, Goodman RB, Steinberg KP, Ruzinski JT, Radella F 2nd, Park DR et al. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;164:1896-903.
39
39. Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest. 2008;118(11):3546-56.
40
40. Karadag F, Karul AB, Cildag O, Yilmaz M, Ozcan H. Biomarkers of systemic inflammation in stable and exacerbation phases of COPD. Lung. 2008;186(6):403-9.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The anti-inflammatory effects of Huang-Lyun (Coptidis Rhizoma, CR) on injured tissue after burn elicitation
- The current status of the combination therapy of frequently used herbal extracts and anti-platelet drug, anti-coagulant drug in ischemic stroke patients hospitalized in oriental medical hospital
- Current State of Pain Treatment in Oriental Medicine
- Pattern Identification of 97 Functional Dyspepsia Patients and the Characteristics of Each Pattern Type
- Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury
- Study of Medical Devices in Traditional Korean Medical Clinics
- An Analysis of Effects on Vision Care Program Including Traditional Korean Treatment for Elementary School Students
- A Comparative Study of Pyeongwi-san, Ijin-tang and Pyeongjintang Extracts on Indomethacin-Induced Gastric Mucosal Lesions in Mice
- Case of Multiple Systemic Atrophy Treated with Korean Medical Treatment and Rehabilitation Therapy
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.