- P-ISSN 1010-0695
- E-ISSN 2288-3339
Objectives: We carried out an observational study of the effects of Nei Guan (P6) and Gong Sun (SP4) acupuncture for the treatment of CINV, preparing for further randomized controlled trial study. This is a case series to explore the changes in the incidence of CINV by acupuncture. Methods: Patients reported a Rhodex index indicating the severity of nausea and vomiting and loss of appetite, before acupuncture, after acupuncture and 1-week follow-up examination. Twelve patients with CINV participated in this study. We included patients receiving chemotherapeutic agents that might induce moderate or severe nausea and vomiting. We conducted 5 treatment sessions with P6 and SP4 acupuncture over the course of 5 days. Results: The median Rhodex score were decreased in 5 patients over time, while we observed loss of appetite of 6 patients were improved over time. During the study, the mean of Rhodex of total patients revealed a decrease of Day 1, Day 7, Day 14; 0.74, 0.68, 0.38, respectively, while the mean of loss of appetite showed a decrease of Day 1, Day 7, Day 14; 5.25, 4.08, 4.00, respectively. Conclusions: The study gives a preliminary data that manual acupuncture of P6 and SP4 may reduce the severity of CINV and loss of appetite, and justifies further study.
1. Morran C, Smith DC, Anderson DA, McArdle CS. Incidence of nausea and vomiting with cytotoxic chemotherapy: a prospective randomised trial of antiemetics. Br Med J 1979;1(6174):1323-1324.
2. Zabernigg A, Gamper EM, Giesinger JM, et al. Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 2010;15(8): 913–920.
3. Dundee JW, Ghaly RG, Fitzpatrick KT, Abram WP, Lynch GA. Acupuncture prophylaxis of cancer chemotherapy-induced sickness. J R Soc Med 1989;82(5):268-271.
4. Shen J, Wenger N, Glaspy J, et al. Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. JAMA 2000;284(21):2755-2761.
5. Nystrom E, Ridderstrom G, Leffler AS. Manual acupuncture as an adjunctive treatment of nausea in patients with cancer in palliative care--a prospective, observational pilot study. Acupuncture Med 2008;26(1):27-32.
6. Streitberger K, Friedrich-Rust M, Bardenheuer H, et al. Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: a randomized controlled singleblind trial. Clin Cancer Res 2003;9(7):2538-2544.
7. Choo SP, Kong KH, Lim WT, Gao F, Chua K, Leong SS. Electroacupuncture for refractory acute emesis caused by chemotherapy. J Altern Complement Med 2006;12(10):963-969.
8. Gottschling S, Reindl TK, Meyer S, et al. Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology - a randomized multicenter crossover pilot trial. Klin Padiatr 2008;220(6):365-370.
9. Yang Y, Zhang Y, Jing NC, et al. Electroacupuncture at Zusanli (ST 36) for treatment of nausea and vomiting caused by the chemotherapy of the malignant tumor: a multicentral randomized controlled trial. Zhongguo Zhen Jiu 2009;29(12):955-958.
10. Wang SB, Chen SP, Gao YH, Luo MF, Liu JL. Effects of electroacupuncture on cardiac and gastric activities in acute myocardial ischemia rats. World J Gastroenterol 2008;14(42):6496-6502.
11. Ouyang A, Xu L. Holistic acupuncture approach to idiopathic refractory nausea, abdominal pain and bloating. World J Gastroenterol 2007;13(40):5360-5366.
12. Rhodes VA, McDaniel RW. The Index of Nausea, Vomiting, and Retching: a new format of the index of Nausea and Vomiting. Oncol Nurs Forum 1999;26(5):889-894.
13. Kaptchuk TJ. Acupuncture: theory, efficacy, and practice. Ann Intern Med 2002;136(5):374-383.
14. Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med 2008;358(23):2482-2494.
15. Ihbe-Heffinger A, Ehlken B, Bernard R, et al. The impact of delayed chemotherapy-induced nausea and vomiting on patients, health resource utilization and costs in German cancer centers. Ann Oncol 2004;15(3):526-536.
16. Sawada NO, Zago MM, Galvão CM, et al. The outcomes of visualization and acupuncture on the quality of life of adult cancer patients receiving chemotherapy [published online September-October, 2010]. Cancer Nurs. doi:10.1097/NCC.0b013e3181d86739.
17. Dhond RP, Kettner N, Napadow V. Neuroimaging acupuncture effects in the human brain. J Altern Complement Med 2007;13(6):603-616.