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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Kaurenoic acid, a Diterpene Derived from Aralia continentalis, Alleviates Lipogenesis in HepG2 Cells.
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2015, v.36 no.4, pp.73-78
(Pusan National University)
(Pusan National University)
(Pusan National University)
(Pusan National University)
(Pusan National University)
(Pusan National University)
(Pusan National University)
Yu,
G.
K.
, Jae,
H.
K.
, Yong,
W.
J.
, Min,
J.
K.
, &
(2015). Kaurenoic acid, a Diterpene Derived from Aralia continentalis, Alleviates Lipogenesis in HepG2 Cells.. Journal of Korean Medicine, 36(4), 73-78.
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Abstract
Objectives: Here we investigated the anti-lipogenic potential of kaurenoic acid (KA), a diterpene derived from Aralia continentalis, in a cellular model of non-alcoholic fatty liver disease. Methods: HepG2 cells were treated with palmitate for 24h to induce intracellular lipid accumulation. To assess the influence of KA on steatotic HepG2 cells, various concentration of KA was co-administered. After palmitate treatment, Intracellular triglyceride content was measured. Expression level of several lipogenic genes, sterol regulatory element-binding transcription factor-1c (SREBP-1c) , acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1) were measured using Western-blot analyses or RT-PCR. Results: Palmitate markedly increased intracellular triglyceride level and expression of related lipogenic genes in HepG2 cells, and which was relieved by co-administered KA. Conclusions: It is conceivable that that KA may have a pharmacological potential to reduce lipid accumulation in non-alcoholic fatty liver disease.
- keywords
- Kaurenoic acid, Aralia continentalis, Non-alcoholic fatty liver disease, HepG2 cell
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