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- E-ISSN 2288-3339
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- E-ISSN2288-3339
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The Anti-emetic Effect of Banhasasim-tang Intravenous Herbal Acupuncture in MTX-induced Rat-Pica Model
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2017, v.38 no.1, pp.34-45
https://doi.org/10.13048/jkm.17004
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(2017). The Anti-emetic Effect of Banhasasim-tang Intravenous Herbal Acupuncture in MTX-induced Rat-Pica Model. Journal of Korean Medicine, 38(1), 34-45, https://doi.org/10.13048/jkm.17004
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Abstract
Objectives: This study aimed to investigate the effect of banhasasim-tang intravenous herbal acupuncture (BST-IVHA) on emesis induced by chemotherapy in rats. Methods: This study used methotrexate(MTX)-induced Rat-Pica model. The rats were randomly allocated into seven groups; normal group, two saline groups, four Banhasasim-tang(BST) groups (groups treated with BST-IVHA). All the experimental animals except those in the normal group were injected with MTX. Those in the pre-treatment groups were treated with saline injection (saline group) or BST-IVHA (BST group) before MTX injection. Those in the post-treatment groups were treated with saline injection or BST-IVHA after MTX injection. Two different dosages of BST-IVHA solution (low dose; BST-1 group, high dose; BST-2 group) were used. The changes in body weight, food intake, and kaolin consumption at 24h, 48h, and 60h were monitored and analyzed. Results: 1. No significant change was found in body weight. 2. The food intake at 48h was increased significantly in the BST-1 pre-treatment group(19.89±0.01g) compared to the pre-saline group(18.68±0.26g). 3. The kaolin consumption was significantly decreased in the BST-1 pre-treatment group at 24h(0.24±0.02g) and 60h(0.36±0.14g), in the BST-2 pre-treatment group at 48h(0.02±0.01g) and 60h(0.80±0.31g) compared to the pre-saline group(24h:0.81±0.37g, 48h:0.76±0.43g, 60h:1.56±0.03g). The kaolin consumption was also significantly decreased in the in the BST-1 post-treatment group at 24h(0.05±0.02g), 48h(0.64±0.06g) and 60h(0.14±0.05g), in the BST-2 post-treatment group at 48h(0.01±0.01g) and 60h(0.01±0.01g) compared to the post-saline group(24h:0.51±0.4g, 48h:3.58±0.33g, 60h:2.5±0.2g). Conclusions: BST-IVHA showed an anti-emetic effect in MTX-induced rat-pica model. This result suggests that BST-IVHA could be an effective treatment for chemotherapy-induced emesis.
- keywords
- Anti-emesis, Banhasasim-tang, Intravenous herbal acupuncture, Chemotherapy, MTX
Reference
1
1. Park JG, Park CI, Kim NK. Oncology. 1st ed. Seoul:Ilchokak. 2009:3, 128.
2
2. Graham KM, Pecoraro DA, Ventura M, Meyer CC. Reducing the incidence of stomatitis using a quality assessment and improvement approach. Cancer Nurs. 1993;16(2:117-22.
3
3. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury:pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9):1995-2025.
4
4. Hockenberry-eaton M, Benner A. Patterns of nausea and vomiting in children: nursing assessment and intervention. Oncol Nurs Forum. 1990;17(4):575-84.
5
5. Kim HJ, Kim HS. Nausea/Vomiting and Self -care in patients with Cancer on Chemotherapy. J Korean Acad Funda Nurs. 2005;12(2):180-5.
6
6. Ackland SP, Schilsky RL. High-dose methotrexate:a critical reappraisal. J Clin Oncol. 1987;5(12):2017-31.
7
7. Jacobs SA, Stoller RG, Chabner BA, Jones DG. 7-Hydroxy methotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high-dose methotrexate. J Clin Incest. 1976;57(2):534-8.
8
8. Kim SH, Kim DH. Traditional oriental medicine's therapy on anticancer agent's side effect. Daejeon University Journal of the institute of Oriental Medicine. 1993;2(1):32-51.
9
9. Bae BC. PyoJunImSangBangJeHak(Clinical Basic of Herb Prescription). Seoul:SeongBoSa. 1995:123-5.
10
10. Meridians & Acupoints Compliation Committe of Korean Medical Colleges. Principles of Meridians & Acupoints; A Guidebook for College Students. 7th ed. Daejeon:JongRyeoNaMu Publishing. 2015;101, 106.
11
11. Yamamoto K, Takeda N, Yamatodani A. Establishment of an Animal Model for Radiation-induced Vomiting in Rats Using Pica. J Radiat Res. 2002;43(2):135-41.
12
12. Lohr L. Chemotherapy-induced nausea and vomiting. Cancer J. 2008;14(2):85-93.
13
13. Kim W. Chemotherapy-induced nausea and vomiting. KSCO News&Education. 2008;4:24-9.
14
14. de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, v Beurden V, Stoter G, et al. Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer. 1997;76(8):1055-61.
15
15. Kim SG. Managements of Chemotherpay Induced Nausea and Vomiting. Korean J Clin Oncol. 2012;8(1):23-9.
16
16. Hornby PJ. Central neurocircuitry associated with emesis. Am J Med. 2001;111(Suppl 8A):106S-12S.
17
17. Kris MG, Radford JE, Pizzo BA, Inabinet R, Hesketh A, Hesketh PJ. Use of an NK1receptor antagonist to prevent delayed emesis after cisplatin. J Natl Cancer Inst. 1997;89(11):817-8.
18
18. Jordan K, Gralla R, Jahn F, Molassiotis A. International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV): Content and implementation in daily routine practice. Eur J Pharmacol. 2014;722:197-202.
19
19. Schwartzberg L. Chemotherapy-induced nausea and vomiting: state of the art in 2006. J Support Oncol. 2006;4(2 Suppl 1):3-8.
20
20. Takahashi T, Hoshi E, Takagi M, Katsumata N, Kawahara M, Eguchi K. Multicenter, phase II, placebo controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin. Cancer Sci. 2010;101(11):2455-61.
21
21. Botrel TE, Clark OA, Clark L, Paladini L, Faleiros E, Pegoretti B. Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT(3)R) in preventing chemotherapy induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis. Support Care Cancer. 2010;19(6):823-32.
22
22. Saito M, Aogi K, Sekine I, Yoshizawa H, Yanagita Y, Sakai H, et al. Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial. Lancet Oncol. 2009;10(2):115-24.
23
23. Shin HS, Lee SB, Ryu KH. Effect of Nei-Guan Acupressure on Nausea, Vomiting and Anorexia in Gynecological Cancer Patients Receiving Chemotherapy. J. East-West Nurs. Res. 2009;15(1):26-33.
24
Park YK, Park KI, Park KS, Hwang DS, Lee CH, Jang JB, et al. A Clinical Study on Two Cases of Chemotherapy Induced Nausea and Vomiting (CINV) and Radiotherapy Induced Nausea and Vomiting (RINV) Patients Treated by Gamihachul-Tang-Gagam-bang. The Journal of Oriental Obstetrics ＆ Gynecology. 2015
25
HG, Wang JH, Park HJ, et al. Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model. Food and Chemical Toxicology. 2011;49(1): 215-221.
26
26. Garcia MK, McQuade J, Haddad R, Patel S, Lee R, Yang PY, et al. Systematic Review of Acupuncture in Cancer Care: A Synthesis of the Evidence. JCO. 2013;31(7):952-60.
27
27. Cheon SY, Zhang XY, Lee IS, Cho SH, Chae YB, Lee HS. Pharmacopuncture for cancer care: a systematic review. Evidence-Based Complementary and Alternative Medicine. 2014;2014:804746.
28
28. Internal Medicine Professors of Korean Medical Colleges. Digestive system in Internal Medicine. Seoul:HanSeong Planning. 2000:84-8.
29
29. Mun JJ, Ahn KS, Kim SH, Uhm HS, Ji GY, Kim SB. SangHanRonJeongHae(Interpretation of Treatise on Febrile Diseases). Seoul:Han UiMunHwaSa. 2003:317-20.
30
30. Lee JS, Kim JS, Ryu BH, Yun SH. Effect of Banhasasimtang Granule on Gastric Emptying in Rats. Korean J. Orient. Int. Med. 2006;27(2):471-9
31
31. Ryu BH, Ryu KW, Kim JS, Yun SH. Evaluation for Therapeutic Effectiveness of Banwhasashim-tang in Functional Dyspepsia. Korean J. Orient. Int. Med. 2003;24(2):329-36
32
32. Jang MU, Im SU. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. Korean J. Orient. Int. Med. 2013;34(4):362-74.
33
33. Lee JH. DongUiImSangNaeGwaHak I(Clinical Internal Medicine of Oriental Medicine I). Seoul:BubIn Books. 1999:271-8.
34
34. Takeda N, Hasegawa S, Morita M, Matsunaga T. Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol. Biochem. Behav. 1993;45(4):817-21.
35
35. Raghavendran HR, Rekha S, Cho HK, Jang SS, Son CG. Ginsenoside rich fraction of Panax ginseng C.A. Meyer improve feeding behavior following radiation-induced pica in rats. Fitoterapia. 2012;83(6):1144-50.
36
36. Kim SG. Managements of chemotherapy induced nausea and vomiting. Korean Journal of Clinical Oncology. 2012;6:23-9.
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