- P-ISSN 1010-0695
- E-ISSN 2288-3339
Objectives: Traditional oriental herbal medicine is used in cancer care to alleviate symptoms. Anorexia is a symptom which is frequently observed in patients with cancer and impairs their quality of life. The objective of this systematic review is to summarize current available evidence to evaluate the effect of traditional oriental herbal medicine on anorexia in cancer patients. Methods: The review evaluated randomized controlled trials (RCTs) measuring the effect of any types of herbal medicine on anorexia in cancer patients within 4 electronic databases and manual search up to December 2015. The Cochrane risk of bias tool (ROB) was used to assess the quality of RCTs. Results: In total, 11 RCTs met the inclusion criteria. All of the studies reported the rate or severity of anorexia improved after treatment in herbal-conventional medicine combined group compared to conventional medicine group. 7 of 11 studies showed between-group statistical differences. The methodological quality of RCTs was insufficient with unclear and high ROB. Conclusions: Traditional oriental herbal medicine may have a potential to improve anorexia in patients with cancer. To confirm the clinical recommendation, further researches with rigorous study design are required to support the effects of herbal medicine.
1. Statistics Korea. The causes of death statistics :deaths and death rates by cause (103 items), by sex and by age(five-year age group). Korean Statistical Information Service. 2016; Available at: URL:http://kosis.kr/statisticsList/statisticsList _01List.jsp?vwcd=MT_ZTITLE&parmTabId=M _01_01#SubCont. Accessed December 5, 2016.
2. National Cancer Center Korea. Cancer survival rates. National Cancer Information Center. 2016; Available at: URL:http://www.cancer. go.kr/mbs/cancer/subview.jsp?id=cancer_040301000000. Accessed December 5, 2016.
3. Choi YJ, Lee JS, Cho SH. Use of Korean Medicine among Cancer Patients. J Korean Oriental Med. 2012;33(3):46-53.
4. Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Oncology (Williston Park). 2001;15(1):1267-72.
5. Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, et al. Prevalence of complementary and alternative medicine use in cancer patients during treatment. Support Care Cancer. 2005;13(10): 806-11.
6. Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How Many Cancer Patients Use Complementary and Alternative Medicine: A Systematic Review and Metaanalysis. Integr Cancer Ther. 2012;11(3): 187-203.
7. Cassileth BR, Deng G. Complementary and alternative therapies for cancer. The oncologist. 2004;9(1):80-89.
8. Chung VC, Wu X, Hui EP, Ziea ET, Ng BF, Ho RS, et al. Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses. Scientific reports. 2015;16(5):doi:10.1038/srep18111
9. Wu X, Chung VC, Hui EP, Ziea ET, Ng BF, Ho RS, et al. Effectiveness of acupuncture and related therapies for palliative care of cancer :overview of systematic reviews. Scientific reports. 2015;5: doi:10.1038/srep16776.
10. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncology nursing forum. 2001;28(3):465-70.
11. Kim Y. Symptom Management for Cancer Patients. Korean J Hosp Palliat Care. 2012;15(2):61-7.
12. Jiménez A, Madero R, Alonso A, Martínez -Marín V, Vilches Y, Martínez B, et al. Symptom clusters in advanced cancer. J Pain Symptom Manage. 2011;42(1):24-31.
13. Kang YH. Encyclopedia of Life Science. 1st ed. Seoul:Academy book. 2008.
14. Lee JJ, Lee JJ. A Phase II study of an herbal decoction that includes Astragali-radix for cancer-associated anorexia in patients with advanced cancer. Integr cancer ther. 2010;9(1):24-31.
15. Mantovani G, Macciò A, Massa E, Madeddu C. Managing cancer-related anorexia/cachexia. Drugs 2001; 61(4):499-514.
16. Jeon JH, Cho CK, Park SJ, Kang HJ, Kim K, Jung IC, et al. A Feasibility Study of Moxibustion for Treating Anorexia and Improving Quality of Life in Patients With Metastatic Cancer: A Randomized Sham -Controlled Trial. Integr cancer ther. 2016;April-June:1-8.
17. Higgins JPT. Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011; Available at: URL:http://www.cochrane-handbook.org. Accessed Feb 15, 2016.
18. Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, et al. NECA's guidance for undertaking systematic reviews and meta -analyses for intervention. Seoul: National Evidence-based Healthcare Collaborating Agency. 2011:65-92.
19. Chen H. An Clinical Analysis on Shenqi Fuzheng Injection Combined with Chemotherapy in Treatment of Malignant Tumor. Anti-tumor Pharmacy. 2013;3(2):143-6.
20. Mao Y, Huang J. The Parallel Controlled Study of Tropisetron combined with Herbs used Externally in Treatment of Emesis and Anorexia Caused by Cisplatin-based Chemotherapy. Journal of Practical Traditional Chinese Internal Medicine. 2013;27(6):11-4.
21. Zhuang SR, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, et al. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. British Journal of Nutrition. 2012;107:712-8.
22. Yao Y. Effects of Feiji Decoction for Soothing the Liver Combined with Psychotherapy on Quality of Life in Primary Lung Cancer Patients. Chin J Lung Cancer. 2012;15(1):27-33.
23. Jiang H, Zhang Y, Xu J, Han F, Gu F, Guo A, et al. The effect of Coix Seed Extract combined with transcatheter arterial chemoembolization in the treatment of hepatic metastases. Modern Oncology. 2012;20(8):1662-5.
24. Wang SW. Clinical Observation of the Efficacy of Tong-tai Decoction in Combination with XELOX Regimen Chemotherapy for Treating Advanced Colorectal Cancer. Nanjing, China: Nanjing University of Chinese Medicine. 2012.
25. Tian JH, Liu LS, Shi ZM, Zhou ZY. A Randomized Controlled Pilot Trial of “Feiji Recipe” on Quality of Life of Non-small Cell Lung Cancer Patients. The American Journal of Chinese Medicine. 2010;38(1):15-25.
26. Liu GD, Xiao GL. Effects of Shengqi Fuzheng Injection Combined Chemotherapy on Patients with Primary Liver Cancer. Progress in Modern Biomedicine. 2010;10(7):1348-50.
27. Li TW, Xiang L, Tong FY, Zhang CH. Effects of Sengqi Fuzheng Injection Combined Chemotherapy on Patients with Advanced Lung Cancer. Progress in Modern Biomedicine. 2009;9(10):1917-9.
28. Fu DZ. Improvement of anorexia and weight reducing in patients with lung cancer by integrated Chinese and Western medicine. Zhejiang Journal of Integrative Traditional Chinese and Western Medicine. 2006;16:471–2.
29. Zhou DH, Lin LZ, Zhou YQ, Luo RC, Liu KF, Jia YJ, et al. Analysis of Short-term Therapeutic Efficacy of Integrated Traditional and Western Medicine in Treating Non-small Cell Lung Cancer. Chinese Journal of Integrated Traditional and Western Medicine. 2005;25(12):1061-5.
30. Kim TY. Chapter 13 Anorexia and weight loss:Kim NG. The guide to cancer management -patient care and palliative treatment. Seoul:Ilchokak. 2009:89-95.
31. Ruiz GV, López‐Briz E, Carbonell SR, Gonzalvez PJL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database of Systematic Reviews. 2013;3CD004310.
32. Choi SD, Won JH. An Oriental Medical Study on the Anorexia An Emphasis on the Etiology and Pathology of the Anorexia. J Korean Oriental Med. 1998;19(2):194-210.
33. Yoon SH, Kim HJ. Translation of “Donguibogam”. 1st ed. Gyeongnam: Donguibogam Publication. 2005:274-5,1210,1239-43.
34. Ohno T, Yanai M, Ando H, Toyomasu Y, Ogawa A, Morita H, et al. Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans. Clin Exp Gastroenterol. 2011;4:291-6.
35. Fujitsuka N, Uezono Y. Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome. Front Pharmacol. 2014;10(5):271.
36. Jeon JH, Yoon J, Cho CK, Jung IC, Kim S, Lee SH, et al. Effect of acupuncture for radioactive-iodine-induced anorexia in thyroid cancer patients: a randomized, double-blinded, sham-controlled pilot study. Integr Cancer Ther. 2015;14(3):221-30.
37. Seong YS, Cho EY, Lee YS, Yang HL, Lee HJ. Effects of Nei-Guan Acupressure on Chemotherapy-related Nausea, Vomiting, and Anorexia in Patients with Lung Cancer. Journal of East-West Nursing Research. 2010;16(1):1-10.
38. Fu J, Wang Z, Huang L, Zheng S, Wang D, Chen S, et al. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 2014;28(9):1275-83.
39. Kurashige S, Akuzawa Y, Endo F. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N′butanolnitrosoamine. Cancer Invest. 1999;17:30-5.
40. Tchekmedyian NS, Hickman M, Siau J, Greco FA, Keller J, Browder H, et al. Megestrol Acetate in Cancer Anorexia, and Weight Loss. Cancer. 1992;69(5):1268-74.