- P-ISSN 1010-0695
- E-ISSN 2288-3339
- 권한신청
- P-ISSN1010-0695
- E-ISSN2288-3339
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Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells
Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.4, pp.52-63
https://doi.org/10.13048/JKOM.PUB.41.4.52
(Dept. of Internal Medicine, College of Korean Medicine, Semyung University)
Kim,
K.
(2020). Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells. 대한한의학회지, 41(4), 52-63, https://doi.org/10.13048/JKOM.PUB.41.4.52
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Abstract
Objectives: In this study, we investigated the effects of Pueraria lobata Ohwi flower extracts (PLFE) on macrophages and their underlying mechanism(s) of action. PLFE increased the production of NO and cytokines (IL-6 and TNF-α) in a dose-dependent manner, indicating its immunostimulatory property. Furthermore, PLFE upregulated iNOS, COX-2, and mitogen-activated protein kinase (MAPK) signaling in RAW264.7 cells. Additionally, PLFE enhanced the phosphorylation of IκBα and subsequent IκBα degradation, thereby enabling the nuclear translocation of NF-κB. Taken together, these findings demonstrate that the immunostimulatory effects of PLFE are mediated by the nuclear translocation of the p65 subunit of NF-κB and subsequent secretion of cytokines (IL-6 and TNF-α), upregulation of iNOS and COX-2, and stimulation of MAPK signaling (JNK, ERK, and p38). Thus, PLFE may be a potential immunostimulatory therapeutic.
- keywords
- Pueraria lobata Ohwi flower, PLFE, immunosimulatory effect
- 투고일Submission Date
- 2020-11-09
- 수정일Revised Date
- 게재확정일Accepted Date
- 2020-11-17
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