- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.4, pp.52-63
https://doi.org/10.13048/JKOM.PUB.41.4.52
(Dept. of Internal Medicine, College of Korean Medicine, Semyung University)
Kim,
K.
(2020). Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells. Journal of Korean Medicine, 41(4), 52-63, https://doi.org/10.13048/JKOM.PUB.41.4.52
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Abstract
Objectives: In this study, we investigated the effects of Pueraria lobata Ohwi flower extracts (PLFE) on macrophages and their underlying mechanism(s) of action. PLFE increased the production of NO and cytokines (IL-6 and TNF-α) in a dose-dependent manner, indicating its immunostimulatory property. Furthermore, PLFE upregulated iNOS, COX-2, and mitogen-activated protein kinase (MAPK) signaling in RAW264.7 cells. Additionally, PLFE enhanced the phosphorylation of IκBα and subsequent IκBα degradation, thereby enabling the nuclear translocation of NF-κB. Taken together, these findings demonstrate that the immunostimulatory effects of PLFE are mediated by the nuclear translocation of the p65 subunit of NF-κB and subsequent secretion of cytokines (IL-6 and TNF-α), upregulation of iNOS and COX-2, and stimulation of MAPK signaling (JNK, ERK, and p38). Thus, PLFE may be a potential immunostimulatory therapeutic.
- keywords
- Pueraria lobata Ohwi flower, PLFE, immunosimulatory effect
- Submission Date
- 2020-11-09
- Revised Date
- Accepted Date
- 2020-11-17
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