- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.4, pp.64-71
https://doi.org/10.13048/JKOM.PUB.41.4.64
(Department of Internal Medicine, Korean Medicine Hospital and School of Korean Medicine)
Han,
C.
(2020). Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation. Journal of Korean Medicine, 41(4), 64-71, https://doi.org/10.13048/JKOM.PUB.41.4.64
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Abstract
Objectives This study was done to look into whether Nrf2 take some role in the anti-lipogenic effect of kaurenoic acid in a nonalcoholic fatty liver disease (NAFLD) cellular model. Materials and Methods We measured the effect of kaurenoic acid on intracellular steatosis and Nrf2 activation. Next, the effect of kaurenoic acid on SREBP-1c and some lipogenic genes in palmitate treated HepG2 cells with or without Nrf2 silencing. Results The increased SREBP-1c expression was significantly decreased by concomitant kaurenoic acid treatment in non-targeting negative control siRNA transfected HepG2 cells. However, kaurenoic acid did not significantly inhibited increased SREBP-1c level in Nrf2 specific siRNA transfected HepG2 cells Conclusions Kaurenoic acid has a potential to activate Nrf2, which may suppress SREBP-1c mediated intracellular steatosis in HepG2 cells.
- keywords
- kaurenoic acid, non-alcoholic fatty liver disease, Nrf2
- Submission Date
- 2020-11-10
- Revised Date
- 2020-11-14
- Accepted Date
- 2020-11-25
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