- P-ISSN 1010-0695
- E-ISSN 2288-3339
- 권한신청
- P-ISSN1010-0695
- E-ISSN2288-3339
논문 상세
Home > 논문 상세
Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.4, pp.64-71
https://doi.org/10.13048/JKOM.PUB.41.4.64
(Department of Internal Medicine, Korean Medicine Hospital and School of Korean Medicine)
Han,
C.
(2020). Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation. 대한한의학회지, 41(4), 64-71, https://doi.org/10.13048/JKOM.PUB.41.4.64
- 다운로드 수
- 조회수
Abstract
Objectives This study was done to look into whether Nrf2 take some role in the anti-lipogenic effect of kaurenoic acid in a nonalcoholic fatty liver disease (NAFLD) cellular model. Materials and Methods We measured the effect of kaurenoic acid on intracellular steatosis and Nrf2 activation. Next, the effect of kaurenoic acid on SREBP-1c and some lipogenic genes in palmitate treated HepG2 cells with or without Nrf2 silencing. Results The increased SREBP-1c expression was significantly decreased by concomitant kaurenoic acid treatment in non-targeting negative control siRNA transfected HepG2 cells. However, kaurenoic acid did not significantly inhibited increased SREBP-1c level in Nrf2 specific siRNA transfected HepG2 cells Conclusions Kaurenoic acid has a potential to activate Nrf2, which may suppress SREBP-1c mediated intracellular steatosis in HepG2 cells.
- keywords
- kaurenoic acid, non-alcoholic fatty liver disease, Nrf2
- 투고일Submission Date
- 2020-11-10
- 수정일Revised Date
- 2020-11-14
- 게재확정일Accepted Date
- 2020-11-25
권호 내 다른 논문
- Effect of 2.5 hr-interval single oral combination treatment of Gamisoyo-san with Tamoxifen on the pharmacokinetics profiles of Tamoxifen in rats
- Rhus Verniciflua Stokes Extract Suppresses Expression of Metalloproteinases, iNOS and COX-2 in THP-1 Cells Via Inhibiting NF-κB and MAPK Phosphorylation
- The Promoting Effect of Rumex japonicas Houttuyn ethanol extract on Hair Growth
- Effect of following food regimen per eight constitution medicine on health outcomes: A German study
- Immunostimulatory effects of the Pueraria lobata flower extract via MAPK signaling in RAW264.7 cells
- Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
- Anatomical Study on Hand Gworeum Skin in Human
- Complementary and Alternative Medicine for treating Low Back Pain with Teaching Exercise: A narrative review
- A Suggestion on the Action Mechanisms of Acupuncture Treatment for Controlling Chemotherapy-Induced Peripheral Neuropathy
- Case Report for Severe Hepatitis A Treated in a Korean Hospital
- KM-based Treatment of Viral Hepatitis A accompanied with Pancreatitis: A case report
- Effect of Nokyongdaebo-tang on chronic anemia in Taeumin wiwansuhan-pyohan disease (胃脘受寒表寒病) patient: a case report
- A Case Report: Effect of Korean Medicine Including Distilled Form of Bosaeng-tang Gagambang on Moderate to Severe Hyperemesis Gravidarum
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.