- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
A review on the treatment of Herbal Medicine for asymptomatically infected COVID-19 patients
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2021, v.42 no.1, pp.99-109
https://doi.org/10.13048/jkm.21007
&
(2021). A review on the treatment of Herbal Medicine for asymptomatically infected COVID-19 patients. Journal of Korean Medicine, 42(1), 99-109, https://doi.org/10.13048/jkm.21007
- Downloaded
- Viewed
Abstract
Objectives: Objective: The purpose of this study is to investigate the treatment of herbal medicine for patients with COVID-19 asymptomatic infections. Method: In English, search engines such as ‘PubMed’, ‘Science Direct’, and ‘Cumulative Index to Nursing and Allied Health Literature (CINAHL)’ were used. In Chinese, search engines such as ‘China National Knowledge Infrastructure (CNKI)’ and Wanfang were used. The keywords for the search engines were ‘COVID-19’, ‘asymptomatic infection’, ‘Korean Medicine’, ‘traditional Chinese medicine’, ‘herbal medicine’, and etc. Only clinical studies using herbal medicine for patients without fever or respiratory symptoms were selected. We excluded the cases that do not fit the research topic. Results: A total of 5 studies were finally selected. Among them, four of them used integrated herbal medicine and Western medicine, and one of the studies treated exclusively for herbal medicine. There were a total of seven prescriptions for herbal medicine used in the study. Outcome variables were used as following: lab test, nucleic acid conversion time, hospitalization period, chest CT, and etc. In the RCT study, herbal medicine and Western medicine decreased nucleic acid conversion time, average hospitalization time compared to the control group, but it was not statistically significant. No other adverse reactions were reported in all studies. Conclusion: According to the results, integrated herbal medicine and Western medicine might be an effective treatment for patients with COVID-19 asymptomatic infection reducing hospitalization period, time of nucleic acid turning negative. No severe adverse effects were reported. However, it is thought that better-designed research will be needed in the future.
- keywords
- COVID-19, asymptomatic infection, herbal medicine, Korean medicine
Reference
1
1. Lee S, Kim T, Lee E, Lee C, Kim H, Rhee H, Park S, Son H, Yu S, Park J, Choo E, Park S, Loeb M, Kim T. Clinical course and molecular viral shedding among asymptomatic and symptomatic patients with SARS-CoV-2infection in a community treatment center in the Republic of Korea. JAMA Intern Med. 2020; 180(11):1–6. doi:10.1001/jamainternmed. 2020.3862
2
2. Oran DP, Topol EJ. Prevalence of Asymptomatic SARS-CoV-2 Infection - A Narrative Review. Ann Intern Med. 2020; 173(5):362-367. doi:10.7326/M20-3012.
3
3. Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, Fan Y, Zheng C. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20:425–434. doi: 10.1016/S1473-3099(20)30086-4
4
4. Lee D, Kim Y, Lee H, Hwang H, Nam S, Kim J. The influence of public fear, and psycho-social experiences during the coronavirus disease 2019 (COVID-19) pandemic on depression and anxiety in South Korea. Kor J Counsel Psychoth. 2020; 32(4): 2119-2156.
5
5. Chen P, Lee N, Cia C, Ko W, Hsueh P. A review of treatment of coronavirus disease 2019 (COVID-19): therapeutic repurposing and unmet clinical needs. Front Pharmacol. 2020; 11:584956. doi: 10.3389/fphar.2020.584956.
6
6. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, Ma K. A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect. 2020. doi: 10.1016/j.jmii. 2020.05.001. Epub ahead of print.
7
7. Jang I, Baik Y, Sun S, Lee J, Han C. An overview of the herbal remedies for severe acute respiratory syndrome (SARS) in WHO official report (2004). Korean J Orient Int Med. 2009; 30(3):571-581. uci: G704-000999.2009. 30.3.014
8
8. Wang Y, Xue J, Dai E, Department of Internal Medicine, The Fifth Hospital of Shijiazhuang City, Hebei. Clinical study on the treatment of patients with novel coronavirus pneumonia and asymptomatic infection with integrated traditional Chinese and western medicine. Hebei J TCM. 2020;42(05):645-649. doi: 10.3969/j.issn.1002-2619. 2020.05.001
9
9. Xie X, Song Y, Ran C, Chen S, Wei D, Wang C, Zhou Z, Ran J, Xiang Y, Yu Z, Zhao Y, Luo X, Tao W, Li Y, Tang J, Liu H. Clinical research of Chaihu Ganlu Decoction on COVID-19 asymptomatic infected patients. JETCM. 2020; 29(11):1888-1890. doi: 10.3969/j.issn.1004-745X.2020.11.003
10
10. Luo X, Liu H, Xie X, Song Y, Ran C, Wei D, Chen S, Xiang Y, Zhao Y, Tang J. Clinical Observation on 50 cases of asymptomatic infected with COVID-19 by treatment of integrated of Traditional Chinese and Western Medicine. J Chengdu Univ of TCM. 2020;43(04):14-18. doi: 10.13593/j.cnki.51-1501/r.2020.04.014
11
11. Chen S, Wei Y, Jiao Y, Li M. A case report on the treatment of a COVID-19 asymptomatic infected child. China’s Naturopathy. 2020;28(14):1-3. doi: 10.19621/j.cnki.11-3555/r.2020. 1401
12
12. Liu Q, Zhang Y, Long Y. A child infected with severe acute respiratory syndrome coronavirus 2 presenting with diarrhea without fever and cough: A case report. Medicine (Baltimore). 2020; 99(33):e21427. doi: 10.1097/MD.0000000000021427.
13
13. Cella L, Gagliardi G, Hedman M, Palma G. Injuries from asymptomatic COVID-19disease: New hidden toxicity risk factors in thoracic radiation therapy. Int J Radiat Oncol Biol Phys. 2020; 108(2):394-396. doi:10.1016/j.ijrobp.2020.06.055.
14
14. Qiu J. Covert coronavirus infections could be seeding new outbreaks. Nature. 2020. doi:10.1038/d41586-020-00822-x. Epub ahead of print.
15
15. Dalskov L, Møhlenberg M, Thyrsted J, Blay-Cadanet J, Poulsen ET, Folkersen BH, Skaarup SH, Olagnier D, Reinert L, Enghild JJ, Hoffmann HJ, Holm CK, Hartmann R. SARS-CoV-2 evades immune detection in alveolar macrophages. EMBO Rep. 2020;21(12):e51252. doi: 10.15252/embr.202051252.
16
16. Han H, Xu Z, Cheng X, Zhong Y, Yuan L, Wang F, Li Y, Liu F, Jiang Y, Zhu C, Xia Y. Descriptive, retrospective study of the clinical characteristics of asymptomatic COVID-19patients. mSphere. 2020; 5(5):e00922-20. doi:10.1128/mSphere.00922-20.
17
17. Meyerowitz EA, Richterman A, Bogoch II, Low N, Cevik M. Towards an accurate and systematic characterisation of persistently asymptomatic infection with SARS-CoV-2. Lancet Infect Dis. 2020; S1473-3099(20)30837-9. doi: 10.1016/S1473-3099(20)30837-9.
18
18. Jang I, Hsing L, Han C. An overview on severe acute respiratory syndrome(SARS) in WHO clinical reports. Korean J Orient Int Med. 2005; 26(2):440-452. uci: G704-000999. 2005.26.2.001
19
19. Korean Institute of Oriental Medicine. TCM treatment trend on COVID-19 in China. 2020. 25, 88.
20
20. Kim D, Chu H, Min B, Moon Y, Park S, Kim K, Park S, Kim Y, Song M, Choi G, Lee E. Telemedicine center of Korean Medicine for treating patients with COVID-19:a retrospective analysis. Integr Med Res. 2020; 9(3):100492. doi: 10.1016/j.imr.2020. 100492.
21
21. Ge H, Wang X, Yuan X, Xiao G, Wang C, Deng T, Yuan Q, Xiao X. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis. 2020;39(6):1011-1019. doi: 10.1007/s10096-020-03874-z.
22
22. Dong Z, Lu X, Tong X, Dong Y, Tang L, Liu M. Forsythiae Fructus: A Review on its phytochemistry, quality control, pharmacology and pharmacokinetics. Molecules. 2017;22(9):1466. doi: 10.3390/molecules22091466.
23
23. Chang H, Yeh C, Sheu F. A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages. J Agric Food Chem. 2009; 57(14):6129-39. doi:10.1021/jf9011399.
24
24. Abe H, Sakaguchi M, Odashima S, Arichi S. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1982; 320(3):266-71. doi:10.1007/BF00510139.
25
25. Hattori T, Furuta K, Hayashi K, Nagamatsu T, Ito M, Suzuki Y. Studies on the antinephritic effects of plant components (6):antinephritic effects and mechanisms of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats (2). Jpn J Pharmacol. 1992; 60(3):187-95. doi: 10.1254/jjp .60.187.
26
26. Jang M, Kim Y, Bae E, Oh T, Choi H, Lee J, Oh H, Lee S. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin -mediated cell adhesion. Molecules. 2014;19(12):20340-9. doi: 10.3390/molecules191220340.
27
27. Ying Z, Li X, Dang H, Wang F, Xu X. Saikosaponin-d affects the differentiation, maturation and function of monocyte-derived dendritic cells. Exp Ther Med. 2014; 7(5):1354-1358. doi: 10.3892/etm.2014.1568.
28
28. Ozaki Y, Rui J, Tang Y, Satake M. Antiinflammatory effect of Forsythia suspensa Vahl and its active fraction. Biol Pharm Bull. 1997; 20(8):861-4. doi: 10.1248/bpb.20.861.
29
29. Ozaki Y, Rui J, Tang Y. Antiinflammatory effect of Forsythia suspensa V(AHL) and its active principle. Biol Pharm Bull. 2000;23(3):365-7. doi: 10.1248/bpb.23.365.
30
30. Abdel-Rahman MK. Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats? Lipids Health Dis. 2011; 10:114. doi: 10.1186/1476-511X-10-114.
31
31. Yurt B, Celik I. Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats. Food Chem Toxicol. 2011; 49(2):508-13. doi: 10.1016/j.fct.2010.11.035.
32
32. Yuan B, Yang R, Ma Y, Zhou S, Zhang X, Liu Y. A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharm Biol. 2017; 55(1):620-635. doi: 10.1080/13880209.2016.1262433.
33
33. Dai Y, Wan S, Gong S, Liu J, Li F, Kou J. Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19. Chin J Nat Med. 2020; 18(12):881-889. doi: 10.1016/S1875-5364(20)60031-0.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Cold-Heat and Excess-Deficiency Pattern Identification Based on Questionnaire, Pulse, and Tongue in Cancer Patients: A Feasibility Study
- Influencing factors of using Korean Medicine services – focusing on the 2017 Korean Medicine Utilization Survey
- Retrospective Statistical Analysis on Patients Admitted to a Korean Medicine Hospital by Traffic Accident
- Gamitaeeumjowee-Tang for weight loss in diabetic patients: A retrospective chart review
- A Theoretical Study on Acupuncture Methods(鍼法) Using Five Transport Points(五輸穴)
- Review Study on the Measurement Tools of Scoliosis: Mainly on Non-radiological Methods
- A review on the treatment of Herbal Medicine for asymptomatically infected COVID-19 patients
- A Case Report of Atopic Dermatitis with Otitis Media with Effusion and Chronic Rhinitis
- Case Report on Complete Response and 5 year Survival of Non-Small Cell Lung Cancer IIIB Patient Treated with Integrative Medicine
- Recovery of an Elderly Kwashiorkor Patient by Korean Medicine: A Case Report
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.