The purpose of this study is to examine whether there is a mediating effect of hopelessness the relationship between perceived stress and suicidal ideation in college students. For this study, a survey was conducted on perceived stress, suicidal ideation, and mental health, self-esteem, problem drinking, and stress among 103 college studentsin Gyeonggi do. The results of this study are as follows. It was found that COVID-19 correlated with perceived stress, hopelessness, and suicidal ideation of college students. The hopelessness completely mediated between perceived stress and suicidal thoughts of college students, which is consistent with previous studies. This study is meaningful in that it confirmed relationship between the perceived stress, hopelessness, and suicidal ideations in college students due to COVID-19, reflecting the new situation of the times. Coronavirus will worsen people's mental health disorders and cause new stress-related disorders. Therefore, mental health researchers, clinicians, and people working in trauma-related fields should find ways to reduce the incidence of coronavirus-related trauma stress and prevent its effects. It is necessary to expand the psychological vaccine program to improve the resilience of the public. Since there are individual differences in resilience, it is necessary to strengthen the psychological vaccine program for each subject considering resilience.