악성 흉막액에서 CEA와 CYFRA 21-1의 진단적 유용성
Diagnostic Utility of Pleural Fluid CEA and CYFRA 21-1 for Malignant Pleural Effusions
최정은 (관동대학교)
김성규 (연세대학교)
박무석 (연세대학교)
김영삼 (연세대학교)
장준 (연세대학교)
김세규 (연세대학교)
김주항 (연세대학교)
황상연 (연세대학교)
문진욱 (연세대학교)
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Abstract
Background:The purpose of this study was to evaluate the usefulness of the pleural fluid carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1) tumor markers as complementary tools for the diagnosis of malignant pleural effusions.Patients and Methods:The levels of pleural and serum CEA and CYFRA 21-1 were prospectively assayed in 222 patients with pleural effusions (150 benign effusions, 57 bronchogenic carcinomas and 15 metastatic carcinomas).Results:The levels of pleural fluid CEA and CYFRA 21-1 in the malignant effusions were significantly higher than those in the benign effusions. With a specificity of 95%, the cut off values for the CEA and CYFRA 21-1 in pleural effusions were 5 and 89 ng/ml, respectively. The diagnostic sensitivities of the pleural fluid CEA and CYFRA 21-1 in malignant effusions were 72 and 54%, respectively, whereas using a combination of the two, the sensitivity increased to 87% (p<0.05).Conclusions : These findings suggest that a combination of the pleural fluid CEA and CYFRA 21-1 in pleural effusions can be useful in the diagnosis of malignant pleural effusions.(Tuberc Respir Dis 2004; 57:32-36)
- keywords
- CEA, CYFRA 21-1, Malignant pleural effusions.
참고문헌
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