Recurrent Erlotinib-Induced Interstitial Lung Disease on Non-Small Cell Lung Cancer
Areum Kim (Inha University)
Jin-Seok Park (Inha University)
Chun Ho Shin (Inha University)
남해성 (인하대학교)
Lucia Kim (Inha University)
조재화 (인하대학교)
Jeong Sun Ryu (Inha University)
곽승민 (인하대학교)
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Abstract
Erlotinib (TarcevaⓇ) has been considered to be a new, promising oral chemotherapy agent for local advanced or metastatic non-small cell lung cancer (NSCLC). Erlotinib is regarded as relatively safe, but interstitial lung disease (ILD) related to erlotinib has been reported on an infrequent basis in Asia. We report an histologically confirmed case of recurrent erlotinib-induced ILD. Although, the patient was highly responsive to the first erlotinib treatment, the therapy was discontinued due to erlotinib-induced ILD. After intravenous high dose methylpredinisolone treatment, ILD was improved rapidly by radiologic studies, but the particular lung cancer re-emerged. We restarted the patient erlotinib on low-dose oral methylpredinisolone, resulting in a recurrence of erlotinib-induced ILD. Our case suggests that re-administration of erlotinib should be performed on a limited basis in patients that have developed ILD on previous use, even if a therapeutic effect can be estimated.
- keywords
- Erlotinib, Lung Diseases, Interstitial, Carcinoma, Non-Small-Cell Lung
참고문헌
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