open access
메뉴ISSN : 0376-4672
An ulcer is defined as loss of epithelium. Although many oral ulcers have similar clinical appearances, their etiologies encompass many disorders, including trauma, infection, immunologic disease, and malignant oral cancer. Oral squamous cell carcinoma(SCC) occupying about 90% of oral cancer, usually manifests as unhealed ulcer over 2 weeks. Oral SCC can metastasize to the cervical neck lymph node, and therefore the surgical therapeutic modality for oral SCC could encompass the neck node dissection as well as wide excision for primary lesions, which should leave the post-operative complication of functional damage like dysphagia and facial deformity. Therefore, it is important to discriminate oral SCC from other ulcerative conditions to make a prompt management. The knowledge for the pathogenesis of the ulcerative lesions could help the clinicians to understand the differences of clinical features and to practice an appropriate therapeutics.
Khandwala, A., Van Inwegen, R.G., Charney, M.R., and Alfano, M.C. 5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety. Oral Surg Oral Med Oral Pathol Oral radiol Endod 1997:83:231-238.
Spruance, S.L., Stewart, J.C., Rowe, N.H., McKeough, M.B., Wenerstrom, G., and Freeman, D.J. Treatment of recurrent herpes simplex labialis with oral acyclovir. J Infect dis 1990;161:185-190.
Byers RM, Weber RS, Andrews T, et al. Frequency and therapeutic implications of "skip metastases" in the neck from squamous carcinoma of the oral tongue. Head Neck. 1997;19:14?9.
Faye-Lund H, Abdelnoor M. Prognostic factors of survival in a cohort of head and neck cancer patients in Oslo. Eur J CancerB Oral Oncol. 1996;2:83-90.
Jung J, Cho NH, Kim J, Choi EC, et al. Significant invasion depth of early oral tongue cancer originated from the lateral border to predict regional metastases and prognosis. Int J Oral Maxillofac Surg. 2009;38:653-60.
Shah JP. Surgical approaches to the oral cavity primary and neck. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S15-8.
Shaha AR, Spiro RH, Shah JP, et al. Squamous carcinoma of the floor of the mouth. Am J Surg. 1984;148:455-9.
Soo KC, Spiro RH, King W, et al. Squamous carcinoma of the gums. Am J Surg. 1988;156:281-5.
Alpsoy, E., Yilmaz, E., and Basaran, E. Interferon therapy for Behcet's disease. J Am Acad Dermatol. 1994,;31:617-619.
Jonsson, R., Mountz, J., and Koopman, W. Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal disease. J Oral Pathol Med. 1990;19:341-350.