ISSN : 0376-4672
Purpose: Delayed intentional replantation was introduced as a new alternative to treat the teeth with severe periodontal involvement. The purpose of this study was to elucidate the possibility of delayed intentional replantation and establish theoretical backgrounds. Materials and Methods: Studies were performed into the following two subjects; Clinical evaluation of patients who underwent delayed intentional replantation using clinical and radiographic data. Severe periodontitis involved teeth were carefully extracted and proper time for delayed replantation was evaluated by analyzing inflammation markers (IL-6, TNF- ). Theoretical studies for efficacy of delayed intentional replantation using (-)-Epigallocatechin-3-gallate (EGCG) for preservation of periodontal ligament cells on root surface by minimizing inflammation and treatment of inflammatory extraction sockets. Results: Meaningful success ratio and survival rate were found in delayed intentional replantation showing reduced bone loss and maintained bone level. Additionally, viability of EGCG applied periodontal ligament cells was much higher than control group. Also, EGCG promoted healing of inflammatory extraction sockets by inhibiting inflammatory cell proliferation. Conclusion: Within the limitations of this study, 1-2 weeks after extraction is an appropriate time to do delayed intentional replantation. Also, EGCG provides helpful effects on viability of periodontal ligament cells and periodontium.
1. Machtei EE, Hausmann E, Dunford R, et al. Longitudinal study of predictive factors for periodontal disease and tooth loss. J Clin Periodontol 1999; 26(6):374-380
2. Lee EU, Lim HC, Lee JS, et al. Delayed intentional replantation of periodontally hopeless teeth: a retrospective study. J Periodontal Implant Sci 2014; 44(1):13-19
3. Wang J, Jiang Y, Chen W, et al. Bacterial flora and extraradicular biofilm associated with the apical segment of teeth with post-treatment apical periodontitis. J Endod 2012; 38(7):954-959
4. Siqueira JF, Jr. Aetiology of root canal treatment failure: why well-treated teeth can fail. Int Endod J 2001; 34(1):1-10
5. Lu DP. Intentional replantation of periodontally involved and endodontically mistreated tooth. Oral Surg Oral Med Oral Pathol 1986; 61(5):508-513
6. Demiralp B, Nohutcu RM, Tepe DI, Eratalay K. Intentional replantation for periodontally involved hopeless teeth. Dent Traumatol 2003; 19(1):45-51
7. Baltacioglu E, Tasdemir T, Yuva P, et al. Intentional replantation of periodontally hopeless teeth using a combination of enamel matrix derivative and demineralized freeze-dried bone allograft. Int J Periodontics Restorative Dent 2011; 31(1):75-81
8. Nagappa G, Aspalli S, Devanoorkar A, et al. Intentional replantation of periodontally compromised hopeless tooth. J Indian Soc Periodontol 2013; 17(5):665-669
9. Kratchman S. Intentional replantation. Dent Clin North Am 1997; 41(3):603-617
10. Yang CS, Wang ZY. Tea and cancer. J Natl Cancer Inst 1993; 85(13):1038-1049
11. Krahwinkel T, Willershausen B. The effect of sugar-free green tea chew candies on the degree of inflammation of the gingiva. Eur J Med Res 2000; 5(11):463-467
12. Jung IH, Yun JH, Cho AR, et al. Effect of (-)-epigallocatechin-3-gallate on maintaining the periodontal ligament cell viability of avulsed teeth:a preliminary study. J Periodontal Implant Sci 2011; 41(1):10-16
13. Jung IH, Lee DE, Yun JH, et al. Anti-inflammatory effect of (-)-epigallocatechin-3-gallate on Porphyromonas gingivalis lipopolysaccharidestimulated fibroblasts and stem cells derived from human periodontal ligament. J Periodontal Implant Sci 2012; 42(6):185-195
14. Dissanayake SC, Che ZM, Choi SH, et al. Evaluation of vitrification for cryopreservation of teeth. J Periodontal Implant Sci 2010; 40(3):111-118
15. Kim DJ, Cha JK, Yang C, et al. Changes in periodontium after extraction of a periodontallyinvolved tooth in rats. J Periodontal Implant Sci 2012; 42(5):158-165
16. Yun JH, Pang EK, Kim CS, et al. Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9and on the formation of osteoclasts. J Periodontal Res 2004; 39(5):300-307
17. Cho AR, Kim JH, Lee DE, et al. The effect of orally administered epigallocatechin-3-gallate on ligatureinduced periodontitis in rats. J Periodontal Res 2013; 48(6):781-789
18. Nasjleti CE, Castelli WA, Blankenship JR. The storage of teeth before reimplantation in monkeys. A histologic study. Oral Surg Oral Med Oral Pathol 1975; 39(1):20-29
19. Han DW, Park YH, Kim JK, et al. Long-term preservation of human saphenous vein by green tea polyphenol under physiological conditions. Tissue Eng 2005; 11(7-8):1054-1064
20. Hyon SH. A non-frozen living tissue bank for allotransplantation using green tea polyphenols. Yonsei Med J 2004; 45(6):1025-1034
21. Han DW, Hyon SH, Park JC, et al. Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds. Biomed Mater 2006; 1(1):R18-29
22. Bae JY, Kanamune J, Han DW, et al. Reversible regulation of cell cycle-related genes by epigallocatechin gallate for hibernation of neonatal human tarsal fibroblasts. Cell Transplant 2009; 18(4):459-469
