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open access
메뉴According to the burst of aged people, researchers have focused on aging-related diseases. Cognitive impairment including Alzheimer’s disease (AD), one of the representative diseases related to aging, has no treatment option until now. Recently, it has been revealed that systemic inflammation plays a fundamental role in the pathogenesis of AD. Previous studies have suggested the association between poor oral health and cognitive impairment. Poor oral health can cause dental caries, chronic periodontitis, multiple tooth loss, and poor chewing ability, etc. Especially, periodontitis is a well-known chronic inflammatory disease and affects cognitive impairment directly and indirectly by inflammatory products mediators. Therefore, reduction of pathogenic microbial burden and inflammatory products by treating periodontitis can be a therapeutic modality to prevent cognitive impairment or to slow down the progression of it. Future studies are necessary to elucidate the causal relations and plausible mechanisms between poor oral health and cognitive impairment.
Drag LL, Bieliauskas LA. Contemporary review 2009: cognitive aging. J Geriatr Psychiatry Neurol 2010;23:75-93.
Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci 2003:26;81-104.
Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011;10:819-28.
Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003;60:1119?1122.
Alzheimer A. Uber eine eigenartige Erkankung der Hirnrinde. Allg Z Psychiat ui Grenzbeg. 1907;64:164-168.
Kamer AR, Craig RG, Dasanayake AP, Brys M, Glodzik-Sobanska L, de Leon MJ. Inflammation and Alzheimer's disease: possible role of periodontal diseases. Alzheimers Dement. 2008;4:242-250.
Chalmers JM, Carter KD, Spencer AJ. Oral diseases and conditions in community- living: Older adults with and without dementia. Spec Care Dentist 2003;23:7-17.
Chapman PJ, Shaw RM. Normative dental treatment needs of Alzheimer patients. Aust Dent J 1991;36:141-144.
Ghezzi EM, Ship JA. Dementia and oral health. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:2-5.
Gordon SR. Survey of dental need among veterans with severe cognitive impairment. Gerodontics 1988;4:158-159.
Horn VJ, Hodge WC, Treuer JP. Dental condition and weight loss in institutionalized demented patients. Spec Care Dentist 1994;14:108-111.
Jette AM, Feldman HA, Douglass C. Oral disease and physical disability in community-dwelling older persons. J Am Geriatr Soc 1993:41:1102-1108.
LOesche WJ, Lopatin DE. Interactions between periodontal disease, medical diseases and immunity in the older individual. Periodontol 2000 1998;16:80-105.
Nordenram G, Ryd-Kjellen E, Johansson G, Nordstrom G, Winblad B. Alzheimer's disease, oral function and nutritional status. Gerondontology 1996;13:9-16.
Ship JA. Oral health of patients with Alzheimer's disease. J Am Dent Assoc 1992;123:53-58.
Warren JJ, Chalmers JM, Levy SM, Blanco VL, Ettinger RL. Oral health of persons with and without dementia attending a geriatric clinic. Spec Care Dentist 1997;17:49-53.
Weyant RJ, Pandav RS, Plowman JL, Ganguli M. Medical and cognitive correlates of denture wearing in older community-dwelling adults. J Am Geriatr Soc 2004;52:596-600.
Whittle JG, Sarll DW, Grant AA, Worthington HV. The dental health of the elderly mentally ill: a preliminary report. Br Dent J 1987;162:381-383.
Perry VH, Cunningham C, Holmes C. Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol 2007;7:161-167.
Perry VH, Teeling J. Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. Semin Immunopathol 2013;35:601-612.
Cunningham C, Hennessy E. Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research. Alzheimers Res Ther 2015;7:33.
Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30-44.
Teixeira FB, Saito MT, Matheus FC, Prediger RD, Yamada ES, Maia CSF, Lima RR. Periodontitis and Alzheimer's Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation. Front Aging Neurosci. 2017;9:327.
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S et al. Correlative memory deficits, <TEX>$A{\beta}$</TEX> elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102.
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356.
Eikelenboom P, Stam FC. Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol. 1982;57:239-242.
McGeer PL, McGeer EG. The amyloid cascadeinflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 2013;126:479-497.
McGeer PL, McGeer E, Rogers J, Sibley J. Antiinflammatory drugs and Alzheimer disease. Lancet 1990;335:1037.
in't Veld B, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T. et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer' s disease. N Engl J Med 2001;345:1515-1521.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL., et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol 2015;14:388-405.
Holmes C. Review: systemic inflammation and Alzheimer's disease. Neuropathol Appl. Neurobiol 2013;39:51-68.
Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol 2015;16:229-236.
VanItallie TB. Alzheimer's disease: innate immunity gone awry? Metabolism 2017;60S:S41-S49.
Marques F, Sousa JC, Sousa N, Palha JA. Bloodbrain-barriers in aging and in Alzheimer's disease. Mol Neurodegener 2013:8;38.
Greenwood J, Heasman SJ, Alvarez JI, Prat A, Lyck R, Engelhardt B. Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain. Neuropathol Appl Neurobiol. 2011:37(1);24-39.
Gaur S, Agnihotri R. Alzheimer's disease and chronic periodontitis: is there an association? Geriatr Gerontol Int 2015;15:391-404.
Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005;19:1329-1331.
Teeling JL, Perry VH. Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience 2009;158:1062-1073.
Jaeger LB, Dohgu S, Sultana R, Lynch JL, Owen JB, Erickson MA, et al. Lipopolysaccharide alters the blood-brain barrier transport of amyloid <TEX>${\beta}$</TEX> protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun 2009;23:507-517.
Sly LM, Krzesicki RF, Brashler JR, Buhl AE, McKinley DD, Carter DB, et al. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res Bull 2001;56:581-588.
Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 2009;73:768-774.
Berton M, Lorette G, Baulieu F, Lagrue E, Blesson S, Cambazard F, et al. Generalized lymphedema associated with neurologic signs (GLANS) syndrome: a new entity? J Am Acad Dermatol 2015;72:333-339.
Pazos P, Leira Y, Dominguez C, Pias-Peleteiro JM, Blanco J, Aldrey JM. Association between periodontal disease and dementia: a literature review. Neurologia 2016;S0213-4853(16)30178-5. doi: 10.1016/j.nrl.2016.07.013 [Epub ahead of print].
Kamer AR, Pirraglia E, Tsui W, Rusinek H, Vallabhajosula S, Mosconi L, et al. Periodontal disease associates with higher brain amyloid load in normal elderly. Neurobiol Aging 2015;36:627-633.
Ganesh P, Karthikeyan R, Muthukumaraswamy A, Anand J. A potential role of periodontal inflammation in Alzheimer's disease: a review. Oral Health Prev Dent 2017;15:7-12.
Sochocka M, Sobczynski M, Sender-Janeczek A, Zwolinska K, Blachowicz O, Tomczyk T, Zietek M, Leszek J. Association between Periodontal Health Status and Cognitive Abilities. The Role of Cytokine Profile and Systemic Inflammation. Curr Alzheimer Res 2017;14:978-990.
Riviere GR, Riviere KH, and Smith KS. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol 2002;17:113-118.
Abbayya K, Puthanakar NY, Naduwinmani S, and Chidambar YS. Association between periodontitis and Alzheimer's disease. N Am J Med Sci 2015;7:241-246.
Rivest S, Lacroix S, Valli?res L, Nadeau S, Zhang J, Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 2000;223:22-38.
Poole S, Singhrao SK, Kesavalu L, Curtis MA, Crean S. Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue. J Alzheimers Dis 2013;36:665-677.
Noble JM, Borrell LN, Papapanou PN, Elkind MS, Scarmeas N, Wright CB. Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III. J Neurol Neurosurg Psychiatry 2009:80(11);1206-1211.
Poole S, Singhrao SK, Kesavalu L, Curtis MA, Crean S. Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue. J Alzheimers Dis 2013:36;665-677.
Singhrao SK, Harding A, Poole S, Kesavalu L, and Crean S. Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer's disease. Mediators Inflamm 2015:137357.
Olsen I, Taubman MA, and Singhrao SK. Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis and Alzheimer's disease. J Oral Microbiol 2016;22:33029.
Kamer AR, Fortea JO, Videla S, Mayoral A, Janal M, and Carmona-Iragui M. Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. Alzheimers Dement (Amst) 2016;2:49-57.
Sparks Stein P, Steffen MJ, Smith C, Jicha G, Ebersole JL, Abner E, et al. Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement. 2012;8:196-203.
Watts A, Crimmins EM, Gatz M. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease. Neuropsychiatr Dis Treat 2008;4:865-876.
Kamer AR, Craig RG, Pirraglia E, Dasanayake AP, Norman RG, Boylan RJ, et al. TNF-a and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. J Neuroimmunol 2009;216:92-97.
Bodet C, Chandad F, Grenier D. Porphyromonas gingivalis-induced inflammatory mediator profile in an ex vivo human whole blood model. Clin Exp Immunol 2006;143:50-57.
D'Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, et al. Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers. J Dent Res 2004;83:156-160.
Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71:1528-1534.
Kim J, Amar S. Periodontal disease and systemic conditions: a bidirectional relationship. Odontology 2006;94:10-21.
Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 2003;61:76-80.
Bullon P, Newman HN, Battino M. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol 2000 2014;64:139-153.
Etemadifar R, Konarizadeh S, Zarei A, Farshidi H, and Sobhani A. Relationship between periodontal status and C-reactive protein and interleuckin-6 levels among atherosclerotic patients in Bandar Abbas, Iran in 2014. Electron Physician 2015;7:1010-1016.
Ahn YB, Shin MS, Han DH, Sukhbaatar M, Kim MS, Shin HS, et al. Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults. Atherosclerosis 2016;251:311-318.
Appleton JP, Scutt P, Sprigg N, and Bath PM. Hypercholesterolaemia and vascular dementia. Clin Sci (Lond) 2017;131:1561-1578.
Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Sacco RL, et al. Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation 2005;111:576-582.
Ford PJ, Gemmell E, Timms P, Chan A, Preston FM, Seymour GJ. Anti-P. gingivalis Response Correlates with Atherosclerosis. J Dent Res 2007;86:35-40.
Syrjala AM, Ylostalo P, Ruoppi P, Komulainen K, Hartikainen S, Sulkava R, Et al. Dementia and oral health among subjects aged 75 years or older. Gerodontology 2012;29:36-42.
Wu F, Lu B. Prospective association of periodontal disease with cardiovascular and all-cause mortality: NHANES III follow-up study. Atherosclerosis 2011;218:536-542.
Gurav AN. Alzheimer's disease and periodontitis - an elusive link. Rev Assoc Med Bras 2014:60(2);173-180.
Thomson WM, Poulton R, Milne BJ, Caspi A, Broughton JR, Ayers KM. Socioeconomic inequalities in oral health in childhood and adulthood in a birth cohort. Community Dent Oral Epidemiol 2004;32:345-353.
Stewart R, Hirani V. Dental Health and Cognitive Impairment in an English National Survey Population. J Am Geriatr Soc 2007;55:1410-1414.
Okamoto N, Morikawa M, Okamoto K, Habu N, Hazaki K, Harano A, et al. Tooth loss is associated with mild memory impairment in the elderly: The Fujiwara-kyo study. Brain Res 2010;1349:68-75.
Okamoto N, Morikawa M, Okamoto K, Habu N, Iwamoto J, Tomioka K, et al. Relationship of tooth loss to mild memory impairment and cognitive impairment: findings from the Fujiwara-kyo study. Behav Brain Funct 2010;6:77.
Grabe HJ, Schwahn C, Volzke H, Spitzer C, Freyberger HJ, John U, et al. Tooth loss and cognitive impairment. J Clin Periodontol 2009;36:550-557.
Minn YK, Suk SH, Park H, Cheong JS, Yang H, Lee S, et al. Tooth loss is associated with brain white matter change and silent infarction among adults without dementia and stroke. J Korean Med Sci 2013;28:929-933.
Lexomboon D, Trulsson M, W?rdh I, Parker MG. Chewing ability and tooth loss: association with cognitive impairment in an elderly population study. J Am Geriatr Soc 2012;60:1951-1956.
Banu RF, Veeravalli PT, Kumar VA. Comparative Evaluation of Changes in Brain Activity and Cognitive Function of Edentulous Patients, with Dentures and Two-Implant Supported Mandibular Overdenture-Pilot Study. Clin Implant Dent Relat Res. 2016;18:580-587.
Kim JM, Stewart R, Prince M, Kim SW, Yang SJ, Shin IS, Et al. Dental health, nutritional status and recent-onset dementia in a Korean community population. Int J Geriatr Psychiatry 2007:22(9);850-855.
Hasegawa Y, Ono T, Hori K, Nokubi T. Influence of Human Jaw Movement on Cerebral Blood Flow. J Dent Res 2007;86:64-68.
Su S, Qi T, Su B, Gu H, Wang J, Yang L. Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice. Neural Regen Res 2014:9(17);1606-1609
Kato T, Usami T, Noda Y, Hasegawa M, Ueda M, Nabeshima T. The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats. Behav Brain Res 1997;83;239-242.
Weijenberg RA, Scherder EJ, Lobbezoo F. Mastication for the mind?The relationship between mastication and cognition in ageing and dementia. Neurosci Biobehav Rev 2011;35:483-497.
Ono Y, Yamamoto T, Kubo KY, Onozuka M. Occlusion and brain function: mastication as a prevention of cognitive dysfunction. J Oral Rehabil 2010;37:624-640.
Gobel S. An electron microscopic analysis of the trans-synaptic effects of peripheral nerve injury subsequent to tooth pulp extirpations on neurons in laminae I and II of the medullary dorsal horn. J Neurosci 1984;4:2281-2290.
Yamazaki K, Wakabayashi N, Kobayashi T, Suzuki T. Effect of Tooth Loss on Spatial Memory and TrkB-mRNA Levels in Rats. Hippocampus 2008;18:542-547.
Onozuka M, Watanabe K, Nagasaki S, Jiang Y, Ozono S, Nishiyama K, et al. Impairment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice. Behav Brain Res 2000;108:145-155.
Watanabe K, Ozono S, Nishiyama K, Saito S, Tonosaki K, Fujita M, et al. The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance. Behav Brain Res 2002;128:19-25.
Ishidaemail N, Ishihara Y, Ishida K, Tada H, Kato Y, Isoda R, et al. Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice. Alzheimer's and Demential 2013;9:851.
Jones JA, Lavallee N, Alman J, Sinclair C, Garcia RI. Caries incidence in patients with dementia. Gerodontology 1993;10:76-82.
Sheiham A, Steele J. Does the condition of the mouth and teeth affect the ability to eat certain foods, nutrient and dietary intake and nutritional status amongst older people? Public Health Nutr 2001;4:797-803.
Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA. Mediterranean Diet and Risk for Alzheimer's Disease. Ann Neurol 2006;59:912-921.
