ISSN : 0376-4672
Neurofibroma is a benign, heterogenous peripheral nerve sheath tumor arising from the connective tissue of peripheral nerve sheaths, especially the endoneurium. Its intraoral occurrence is uncommon and its occurrence within mandible is extremely rare. A case of solitary intraosseous neurofibroma of the mandible involving masticator space in a 8-year-old male is reported. He was referred from a private local clinic with a chief complaint of limitation in opening of the mouth. Panoramic and cone-beam computed tomographic images showed unilocular radiolucent lesion with scalloped border at the right mandibular ramus, connected posteriorly to the enlarged mandibular foramen and anteriorly to the mandibular canal. T1-weighted magnetic resonance images showed soft tissue mass of isointensity compared with muscles. Contrast-enhanced T1-weighted images showed peripheral enhancement and T2-weighted images showed the heterogeneous hyperintense mass with extension between lateral and medial pterygoid muscles. The tumor was surgically removed under general anesthesia and diagnosed to be neurofibroma at the biopsy.
1. Imaizumi A, Kodama S, Sakamoto J, Sasaki Y, Otonari-Yamamoto M, Kuribayashi A, Kurabayashi T, Sano T. Imaging findings of benign peripheral nerve sheath tumor in jaw. Oarl Surg Oral Med Oral Pathol Oral Radiol 2013;116:369-376.
2. White SC, Pharoah MJ. Oral radiology: Principles and interpretation. 7th ed. Elsevier; 383-386,2014.
3. Ferner RE, O'Doherty MJ. Neurofibroma and schwannoma. Curr Opin Neurol 2002;15:679-684.
4. M urphy MD, Smith WS, Smith SE, Karnsdorf MJ, Temple HT. From the archives of the AFIP. Imaging of muscuolskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 1999;19:1253-1280.
5. Lin J, Martel W. Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonogarphy. AJR Am J Roentgenol 2001;176:75-82.
6. Franco T, de Freitas Filho SAJ, Muniz LB, de Faria PR, Loyola AM, Cardoso SV. Oral peripheral nerve sheath tumors: a clinicopathological and immunohistochemical study of 32 cases in a Brazillian population. J Clin Exp Dent 2017;9:e1459-1465.
7. Pilavaki M, Chourmouzi D, Kiziridou A, Skordalaki A, Zarampoukas T, Drevelengas A. Imaging of peripheral nerve sheath tumors with pathologic correlation.: pictorial review. Eur J Radiol 2004;52:229-239.
8. Banks KP. The target sign: extremity. Radiology 2005;234:899-900.
9. Ellis GL, Abrams AM, Melrose RJ. Intraosseous benign neural sheath neoplasms of the jaws. Report of seven new cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 1977;44:731-743.
10. Polak M, Polak G, Brocheriou C, Vigneul J. Solitary neurofibroma of the mandible: case report and review of the literature. J Oral Maxillofac Surg 1989;47:65-68.
11. S umitomo S, Ohno K, Mizuatni G, Takahisa O, Yamada K, Takai Y. Solitary neurofibroma of the mandible. Asian J Oral Maxillofac Surg 2006;18:142-145.
12. Gujjar PK, Hallur JM, Patil ST, Dakshinamurthy SM, Chande M, Pereira T, Zingade J. The soliatry variant of mandibular intraosseous neurofibroma: report of a rare entity. Case Rep Dent 2015;2015:520261.
13. Kami Y, Chikui T, Okamura K, Kubota Y, Oobu K, Yabuuchi H, Nakayama E, Hashimoto K, Yoshiura K. Imaging findings of neurogenic tumors in the head and neck ergion. Dentomaxillofac Radiol 2012;41:18-23.
14. Metwaly H, Cheng J, Maruyama S, Yamazaki M, Essa A, Abe T, Babkair H, Hoshina H, Takagi R, Hayashi T, Saku T. Central neurofibroma of the mandible: report of a case and review of the literature. J Oral Maxillofac Surg Med Pathol 2013;25:294-298.
15. Pujari VB, Thakkannavar S, Hormuzdi D. Intraosseous solitary neurofibroma in ramus of mandible: a unique clinical case report. Asian J Dent Sci 2019;2:1-6.
16. J ee WH, Oh SN, McCauely T, Ryu KN, Suh JS, Lee JH, Park JM, Chun KA, Sung MS, Kim K, Lee YS, Kang YK, Ok IY, Kim JM. Extraaxial neurofromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol 2004;183:629-633.
17. Abdel Razek AA. Computed tomography and magnetic resonance imaging of lesions at masticator space. Jpn J Radiol 2014;32:123-137.
