ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

左歸飮加味方이 실험적 재생불량성빈혈에 미치는 영향

Effects of Juakium-derivative on Experimental Aplastic Anemia

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.1, pp.133-144
박신명 (경희대학교)
김영철 (경희대학교)
이장훈 (경희대학교)
우홍정 (경희대학교)
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Abstract

Objectives : The Korean traditional medicinal herbs have been used to improve the function of hematopoietic system. The purpose of this study is to examine the hematopoietic effects of Juakium-derivative on aplastic anemia.Methods : In vitro, after bone marrow cells of mice with aplastic anemia induced by benzene were cultured with Juakium-derivative, we measured the gene expressions of hematopoietic cytokines, the intracelluar TPO and SCF expression and the colony number of CFU-GEMM and BFU-E.Results : The results are summerized as follow:1. The gene expressions of hematopoietic cytokines(TPO, c-mpl, SCF, c-kit, IL-3, EPO, EpoR, GM-CSF) and the TPO and SCF expression of the group treated with Juakium-derivative increased significantly more than those of controll group.2. The colony number of CFU-GEMM and BFU-E in the rEPO plus rIL-3 plus Juakium-derivative group increased significantly, compared with the only rEPO plus rIL-3 group.Conclusion : It was acknowledged that Juakium-derivative has hematopotentiating effects on aplastic anemia induced by benzene and it is expected that Juakium-derivative can be used clinically to the patient with hematopoietic system disorder. This study could also be used further as a important research data for korean oriental medicine about hematopotentiating. The exact mechanism explaining our study would be studied furthermore.

keywords
Juakium-derivative, aplastic anemia, hematopoietic effects, hematopoietic cytokines, Juakium-derivative, aplastic anemia, hematopoietic effects, hematopoietic cytokines


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