- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Juakium-derivative on Experimental Aplastic Anemia
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.1, pp.133-144
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(2002). Effects of Juakium-derivative on Experimental Aplastic Anemia. Journal of Korean Medicine, 23(1), 133-144.
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Abstract
Objectives : The Korean traditional medicinal herbs have been used to improve the function of hematopoietic system. The purpose of this study is to examine the hematopoietic effects of Juakium-derivative on aplastic anemia.Methods : In vitro, after bone marrow cells of mice with aplastic anemia induced by benzene were cultured with Juakium-derivative, we measured the gene expressions of hematopoietic cytokines, the intracelluar TPO and SCF expression and the colony number of CFU-GEMM and BFU-E.Results : The results are summerized as follow:1. The gene expressions of hematopoietic cytokines(TPO, c-mpl, SCF, c-kit, IL-3, EPO, EpoR, GM-CSF) and the TPO and SCF expression of the group treated with Juakium-derivative increased significantly more than those of controll group.2. The colony number of CFU-GEMM and BFU-E in the rEPO plus rIL-3 plus Juakium-derivative group increased significantly, compared with the only rEPO plus rIL-3 group.Conclusion : It was acknowledged that Juakium-derivative has hematopotentiating effects on aplastic anemia induced by benzene and it is expected that Juakium-derivative can be used clinically to the patient with hematopoietic system disorder. This study could also be used further as a important research data for korean oriental medicine about hematopotentiating. The exact mechanism explaining our study would be studied furthermore.
- keywords
- Juakium-derivative, aplastic anemia, hematopoietic effects, hematopoietic cytokines, Juakium-derivative, aplastic anemia, hematopoietic effects, hematopoietic cytokines
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