- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effect of DanSamSaMul-Tang on Hematopoiesis
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.1, pp.145-155
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(2002). The Effect of DanSamSaMul-Tang on Hematopoiesis. Journal of Korean Medicine, 23(1), 145-155.
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Abstract
ObjectivesThe Korean traditional medicinal herbs and some formulas have been used to improve the function of the hematopoietic system.The present research is to examine the effect of DSSMT as a biological response modifier related to hematopotentiating function using bone marrow cell as a testing system.MethodsMice with leukopenia and thrombocytopenia induced by CTX were treated with DanSamSaMul-Tang Extracts. Then we observed cytokines mRNA expression level, the number of CFU-GEMM and BFU-E, and the expression of TPO and SCF in bone marrow cells of mice.Results and conclusionsIn DSSMT group, the gene expressions of hematopoietic cytokines was increased significantly and the number of CFU-GEMM and BFU-E of DSSMT group was significantly increased compared to the group treated only with EPO and IL-3. The expression of TPO and SCF in group treated with DSSMT was increased than those of controlled group. In conclusion, we knew that DSSMT has the good effect on hematopoietic system. This could also be used as a important research data for Korean oriental medicine about hematopotentiating.
- keywords
- DSSMT, hematopoiesis, hematopoietic cytokines, DSSMT, hematopoiesis, hematopoietic cytokines
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