ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

丹蔘四物湯이 조혈작용에 미치는 영향

The Effect of DanSamSaMul-Tang on Hematopoiesis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.1, pp.145-155
유재연 (경희대학교)
김영철 (경희대학교)
이장훈 (경희대학교)
우홍정 (경희대학교)
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Abstract

ObjectivesThe Korean traditional medicinal herbs and some formulas have been used to improve the function of the hematopoietic system.The present research is to examine the effect of DSSMT as a biological response modifier related to hematopotentiating function using bone marrow cell as a testing system.MethodsMice with leukopenia and thrombocytopenia induced by CTX were treated with DanSamSaMul-Tang Extracts. Then we observed cytokines mRNA expression level, the number of CFU-GEMM and BFU-E, and the expression of TPO and SCF in bone marrow cells of mice.Results and conclusionsIn DSSMT group, the gene expressions of hematopoietic cytokines was increased significantly and the number of CFU-GEMM and BFU-E of DSSMT group was significantly increased compared to the group treated only with EPO and IL-3. The expression of TPO and SCF in group treated with DSSMT was increased than those of controlled group. In conclusion, we knew that DSSMT has the good effect on hematopoietic system. This could also be used as a important research data for Korean oriental medicine about hematopotentiating.

keywords
DSSMT, hematopoiesis, hematopoietic cytokines, DSSMT, hematopoiesis, hematopoietic cytokines


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