ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

化肝煎이 아세트아미노펜에 의한 간독성에 미치는 영향

Protective Effect of Whagan-Jeon (huaganjian) on Acetaminophen-induced Hepatotoxicity

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.3, pp.451-460
박철수 (동국대학교)
김기열 (동국대학교)
이채중 (동국대학교)
안중환 (동국대학교)
김종대 (동국대학교)
남경수 (동국대학교)
  • 다운로드 수
  • 조회수

Abstract

Objective : This study was performed to investigate the activity of Whagan-Jeon(huaganjian) in the protection against acetaminophen(AAP)-induced hepatoxicity and the possible mechanisms in vivo.Methods : The following were performed; Serum ALT, depletion of hepatic glutathione(GSH) levels, the microsomal p-nitrophenol hydroxylation activity, microsomal aniline hydroxylation activity, genomic DNA fragmentation and its reversal, hepatic glutathione-S-transferase(GST) activity, and hepatic NAD(P)H:quinone oxidoreductase (QR) activityResults : Whagan-Jeon(huaganjian) protected against AAP-induced hepatotoxicity by the increase of GSH levels, inhibition of P450 2E1-specific metabolic activities, attenuation of hepatic DNA damage, and induction of GST and QR activities in vivo. Conclusions : In conclusion, Whagan-Jeon(huaganjian) was effective in protection against AAP-induced hepatoxicity

keywords
Whagan-Jeon(huaganjian), acetaminophen(AAP), hepatotoxicity, Whagan-Jeon(huaganjian), acetaminophen(AAP), hepatotoxicity


  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

대한한의학회지