- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Protective Effect of Whagan-Jeon (huaganjian) on Acetaminophen-induced Hepatotoxicity
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.3, pp.451-460
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(2002). Protective Effect of Whagan-Jeon (huaganjian) on Acetaminophen-induced Hepatotoxicity. Journal of Korean Medicine, 23(3), 451-460.
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Abstract
Objective : This study was performed to investigate the activity of Whagan-Jeon(huaganjian) in the protection against acetaminophen(AAP)-induced hepatoxicity and the possible mechanisms in vivo.Methods : The following were performed; Serum ALT, depletion of hepatic glutathione(GSH) levels, the microsomal p-nitrophenol hydroxylation activity, microsomal aniline hydroxylation activity, genomic DNA fragmentation and its reversal, hepatic glutathione-S-transferase(GST) activity, and hepatic NAD(P)H:quinone oxidoreductase (QR) activityResults : Whagan-Jeon(huaganjian) protected against AAP-induced hepatotoxicity by the increase of GSH levels, inhibition of P450 2E1-specific metabolic activities, attenuation of hepatic DNA damage, and induction of GST and QR activities in vivo. Conclusions : In conclusion, Whagan-Jeon(huaganjian) was effective in protection against AAP-induced hepatoxicity
- keywords
- Whagan-Jeon(huaganjian), acetaminophen(AAP), hepatotoxicity, Whagan-Jeon(huaganjian), acetaminophen(AAP), hepatotoxicity
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