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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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金水六君煎이 ovalbumin으로 誘發된 mice의 喘息에 미치는 影響

Effects of Kumsooyukkun-jeon on Asthma Induced by Ovalbumin in Mice

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2002, v.23 no.3, pp.522-536
김춘석 (경산대학교)
최해윤 (경산대학교)
김종대 (경산대학교)
김춘석, 최해윤, & 김종대. (2002). 金水六君煎이 ovalbumin으로 誘發된 mice의 喘息에 미치는 影響. 대한한의학회지, 23(3), 522-536.
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Abstract

Objectives : In order to study the effects of Kumsooyukkun-jeon on asthma.Methods : Asthma was induced to Balb/c mouse with ovalbumin using method of Hatfield et al. The histological profiles of lung and trachea, numbers of cellular compartments in the bronchoalveolar lavage fluid(BALF), numbers and morphology of the mast cells in the trachea, numbers of mucous-secretory cell in the bronchus, morphology of the bronchus, ultramicroscopical appearance of surface of trachea and number of cilia and mucous-secretory cells by scanning electron microscope. Results : Hypertrophy of mucous membrane of trachea and bronchus and bronchioles in the lung, peritracheal, peribronchus and peribronchiolar inflammatory cell infiltration, and mucoid exudate deposit in the lumen were observed in control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups.Cellular compartments including neutrophil and eosinophil were increased in the BALF of control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups.Degranulation and decreasing of the numbers of mast cells were detected in the trachea of control groups. However, these phenomena were recovered in the Kumsooyukkun-jeon groups.Shedding, decreasing of cilia cell and increasing of mucous-secretory cells in the surface of the trachea of control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups.Conclusions : It is considered that Kumsooyukkun-jeon has somewhat favorable effects on the asthma.

keywords
Kumsooyukkun-jeon(j nshu li j n-ji n in chinese), Asthma, ovalbumin, Broncho-alveolar lavage fluid(BALF), Kumsooyukkun-jeon(j nshu li j n-ji n in chinese), Asthma, ovalbumin, Broncho-alveolar lavage fluid(BALF)


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