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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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巨刺法에 의한 電鍼刺戟이 白鼠의 formalin 誘發 痛症에 對한 抑制機轉

Contralateral Heterotropic Electroacupuncture Modulates Formalin Induced Pain in the Rat

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.2, pp.193-203
류영수 (원광대학교)
류영수. (2003). 巨刺法에 의한 電鍼刺戟이 白鼠의 formalin 誘發 痛症에 對한 抑制機轉. 대한한의학회지, 24(2), 193-203.
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Abstract

Objectives: In this study, we investigated the effect and pathway of contralateral heterotropic electroacpuncture (EA) on pain induced by formalin in rats. Methods: Acu-points in the right forepaws, HT 7 and PC 7, were stimulated with 3~4mA, 2ms, and 10Hz after 5% formalin(50ul)s.c injection to the left hind paw. in addition, it was investigated whether the dorsolateral funiculus (DLF), as known to the descending inhibition, mediates analgesic effects of the contralateral heterotropic EA, or a administration of naltrexone, a opioid antagonist, blocks the effect of EA. Results:The results showed that contralateral heterotropic electroacpuncture (EA) inhibited late phase (63.311.7%) of pain induced by formalin in the behavioral test, but Sham-EA had little effect on pain behavior(85.616.8%) and no analgesic effects after transection of the dorsolateral funiculus (95.718.7%). The pretreatment of naltrexone (10mg/kg, i.p.) could not inhibit the analgesic effects of EA on formalin inducedpain behavior (70.713.1%). Also, EA suppressed the increased expression of cFos like protein (cFL) in the dorsal horn after formalin injection, but not Sham-EA. Suppressed expressions of cFL in the spinal cord were eliminated after transection of the ipsilateral dorsolateral funiculus at T10 - 11 levels. However, pretreatment of naltrexone could not prevent the suppressive expressions of cFL at the spinal cord. Conclusions: These results suggest that the analgesic effect of contralateral heterotropic electroacpuncture may be modulated through the dorsolateral funiculus constituting the descending inhibition.

keywords
contralateral hetetrotropic stimulation, electroacupuncture(EA), formalin induced pain, immediate early gene, c-fos, contralateral hetetrotropic stimulation, electroacupuncture(EA), formalin induced pain, immediate early gene, c-fos


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