- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Neuroprotective Effects of Angelicae gigantis Radix on Focal Cerebral Ischemia in the Rat
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.2, pp.204-212
(2003). The Neuroprotective Effects of Angelicae gigantis Radix on Focal Cerebral Ischemia in the Rat. Journal of Korean Medicine, 24(2), 204-212.
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Abstract
Current therapy for acute ischemic stroke is highly focused on neuroprotective agents, and many herbal medicines have been challenged for experimental models. The aim of this study is to investigate wheather Angelicae gigantis Radix can protect nerve cells against ischemic neural damage of middle cerebral artery occlusion (MCAO) in rats' brains. Rats were treated with Angelicae gigantis Radix immediately after 2 hours of MCAO for 7 days. On 7th days, the brains of rats were sliced through the hippocampus and were dyed by c-Fos immunohistochemistry stain and Cresyl violet stain for microscopic examination. Each number of viable neurons and c-Fos immunoreactive cells in CA1 regions was counted. MCAO caused significant decrease in density of neurons and c-Fos immunoreactive cells compared to those of sham-operated rats. Administration of Angelicae gigantis Radix significantly elevated MCAO-induced decrease in density of neurons and c-Fos immunoreactive cells. These results suggest that the neuroprotective effect of Angelicae gigantis Radix against focal cerebral ischemia is related to c-fos gene expression. Thus, these findings indicate that Angelicae gigantis Radix can be used for treatment and prevention of ischemia.
- keywords
- Angelicae gigantis Radix, cerebral ischemia, neuroprotective effect, Angelicae gigantis Radix, cerebral ischemia, neuroprotective effect
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