- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Inhibitory Effect of Achyranthes Bidentata Extracts on Cytochrome P450-Catalyzed Reactions in Human Liver Microsomes
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.2, pp.40-46
(2003). The Inhibitory Effect of Achyranthes Bidentata Extracts on Cytochrome P450-Catalyzed Reactions in Human Liver Microsomes. Journal of Korean Medicine, 24(2), 40-46.
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Abstract
Objective: Achyranthes bidentata (Usul) has been used as anti-arthritic, antiallerigic, antidiueriects, and so on. Recently extracts of Achyranthes bidentata showed anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods: We therefore evaluated the inhibitory potential of ethanol extracts of Achyranthes bidentata on cytochrome P450 (CYP) isoforms-catalyzed reactions, which relate to cause cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4 using human liver microsomal preparations. Results: The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 μg/ml, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chlorozoxazone 6-hydroxylation with IC50s of 970.5 μg/ml and 821.4 μg/ml, respectively.Conclusions: these results suggest that extracts of Achyranthes bidentata have inhibitory effects on CYP-catalyzed reaction, especially CYP1A2 and CYP2E1 in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention followed by decreasing reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata. However, further evaluation is necessary to demonstrate and to confirm its effects in human.
- keywords
- Achyranthes bidentata, cytochrome P450, Herb-drug interactions, Achyranthes bidentata, cytochrome P450, Herb-drug interactions
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