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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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흰쥐의 식이성 고지혈증에 대한 蒲黃의 예방 효과

Preventive Effects of Typhae Pollen on the Diet-induced Hyperlipidemia in Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.2, pp.32-39
신형섭 (세명대학교)
서일복 (세명대학교)
신형섭, & 서일복. (2003). 흰쥐의 식이성 고지혈증에 대한 蒲黃의 예방 효과. 대한한의학회지, 24(2), 32-39.
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Abstract

Objectives: In Oriental Medicine, hyperlipidemia is considered as the phlegm stagnancy(痰飮) and blood stasis(瘀血). Typhae Pollen helps remove blood stasis and hemorrhage and it also has an effect of relieving pains caused by blood stasis. The purpose of this study is to investigate the preventive effects of Typhae Pollen on diet-induced hyperlipidemia in rats.Methods: Thirty-two male Sprague-Dawley rats were divided into normal, control and treated group. Control and treated group were fed with 1.5% cholesterol diet during 4 weeks, and also administrated with extract of Typhae Pollen in treated group during same period.Blood samples were collected from each of animals at 0 and 4 weeks and used for the blood chemical analysis. Animals were sacrificed at 4 weeks and chemical analysis was performed on the collected liver samples.Results: The serum total cholesterol(122.45±4.96㎎/㎗), LDL-cholesterol(54.27±4.95㎎/㎗), triglyceride (122.00±7.33㎎/㎗) values of treated group were significantly decreased compared with the serum total cholesterol(147.91±7.22㎎/㎗), LDL-cholesterol (81.91±8.34㎎/㎗), triglyceride(169.27±12.34㎎/㎗) values of control group. The liver total cholesterol(230.18±18.81㎎/㎗) and triglyceride(305.73±26.45㎎/㎗) values of treated group were significantly increased compared with the liver total cholesterol(178.54±10.11㎎/㎗) and triglyceride(300.09±19.94㎎/㎗) values of control group.Conclusions: On the basis of these results, it is confirmed that Typhae Pollen has the preventive effects on the diet-induced hyperlipidemia in rats.

keywords
Typhae Pollen, hyperlipidemia, preventive effects, cholesterol


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