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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450약물 대사효소에 대한 억제작용

The Inhibitory Effect of Achyranthes Bidentata Extracts on Cytochrome P450-Catalyzed Reactions in Human Liver Microsomes

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.2, pp.40-46
김경아 (경희대학교)
김경아. (2003). 인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450약물 대사효소에 대한 억제작용. 대한한의학회지, 24(2), 40-46.
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Abstract

Objective: Achyranthes bidentata (Usul) has been used as anti-arthritic, antiallerigic, antidiueriects, and so on. Recently extracts of Achyranthes bidentata showed anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods: We therefore evaluated the inhibitory potential of ethanol extracts of Achyranthes bidentata on cytochrome P450 (CYP) isoforms-catalyzed reactions, which relate to cause cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4 using human liver microsomal preparations. Results: The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 μg/ml, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chlorozoxazone 6-hydroxylation with IC50s of 970.5 μg/ml and 821.4 μg/ml, respectively.Conclusions: these results suggest that extracts of Achyranthes bidentata have inhibitory effects on CYP-catalyzed reaction, especially CYP1A2 and CYP2E1 in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention followed by decreasing reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata. However, further evaluation is necessary to demonstrate and to confirm its effects in human.

keywords
Achyranthes bidentata, cytochrome P450, Herb-drug interactions, Achyranthes bidentata, cytochrome P450, Herb-drug interactions


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