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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Effects of Water Extract of Genus Panax on Rat Blood Vessels

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.60-71





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Abstract

Objectives : We have examined the relaxational response to the water extract of genus Panax in rat thoracic aorta and mesenteric artery.Methods : Segments of thoracic aorta and mesenteric artery obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph.Results : We found that the thoracic aorta segments responded to the water extract of genus Panax with a dose-dependent vasorelaxation. At 10-5M 5-hydroxytrptamine (5-HT), the maximal contraction force were 94.9% of the maximum KCl-response. At 10-5M 5-HT - induced contraction, The contractile response of thoracic aortic rings were inhibited by 54.7%, 36.3% and 31.3% after addition of the high concentration (100 mg/ml) of water extract of Panax ginseng, Panax japonicus and Panax quinquefolium. The contractile response of mesenteric arteries were inhibited by 88.3%, 87.7%, and 70.3% after addition of the high concentration (100 mg/ml) of water extract of Panax ginseng, Panax japonicus and Panax quinquefolium.Conclusions : In conclusion, water extract of genus Panax - induced relaxation in the isolated rat thoracic aorta and mesenteric artery were composed of endothelium - independent relaxation and dose - dependent relaxation.

keywords
genus Panax, 5-Hydroxytryptamine, Phenylephrine, relaxation, genus Panax, 5-Hydroxytryptamine, Phenylephrine, relaxation


Reference

1

(1995) 神農本草經輯註., 人民衛生出版社

2

(1987) 동양의학연구원,

3

(1998) 대한약전 제7개정,

4

(2000) 농수산물무역정보 (http://www.kati.net),

5

(2000) or=#000000>한국인삼수출입실적 (or=#000000>인삼관련 속보 http://www.insam.or.kr),

6

(2000) 원색한국본초도감, 교학사

7

(1996) 최신고려인삼(성분 및 효능편),

8

(2000Dec) Effects of Panax notoginseng saponins on vascular endothelial cells in vitro,

9

(2001Jun) Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries,

10

(2001jan) Involvement of Ca2+-activated K+ channels in ginsenosides-induced aortic relaxation in rats,

11

(1999feb;12;367) Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta role of K+ channels,

12

(1996jul) Effects of saponins from stems and leaves of Panax quinquefolium L .on the contraction of rabbit aortic strips,

13

(1998Mar) Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle,

14

(1997dec) Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway,

15

(1995jul) Effects of ginsenosides on vasodilator nerve actions in the rat perfused mesentery are mediated by nitric oxide,

16

(1995May) Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit,

17

(1995dec) Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs,

18

(1999) Acute vasorelaxant effects of metformin and attenuation by stimulation of sympathetic agonist release,

19

(1988mar;9) Depressant actions of Panax notoginseng saponins on vascular smooth muscles,

20

(1985dec;6) Effect of the total saponins of Panax notogiseng on contraction of rabbit aortic strips,

21

(2000May) Antioxidant effects of Chinese traditional medicine focus on trilinolein isolated from the Chinese herb sanchi (Panax pseudoginseng). ,

22

(1996aug) Pulmonary protective and vasodilator effects of a standardized Panax ginseng preparation following artificial gastric digestion,

23

Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury,

24

(1995May) Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum,

25

(1995) Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta,

26

(198614) Cardiovascular pharmacology of Panax notoginseng,

27

(2003jun) Screening and Identification of Novel Genes Involved in Biosynthesis of Ginsenoside in Panax ginseng Plant. ,

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