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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Panax 속 한약재가 흰주 혈관운동성에 미치는 영향에 관한비교 연구

The Effects of Water Extract of Genus Panax on Rat Blood Vessels

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.1, pp.60-71
유기덕 (유한의원)
최호영 (경희대학교)
이재성 (한국과학기술연구원)
안덕균 (경희대학교)
김형환 (경희대학교)
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Abstract

Objectives : We have examined the relaxational response to the water extract of genus Panax in rat thoracic aorta and mesenteric artery.Methods : Segments of thoracic aorta and mesenteric artery obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph.Results : We found that the thoracic aorta segments responded to the water extract of genus Panax with a dose-dependent vasorelaxation. At 10-5M 5-hydroxytrptamine (5-HT), the maximal contraction force were 94.9% of the maximum KCl-response. At 10-5M 5-HT - induced contraction, The contractile response of thoracic aortic rings were inhibited by 54.7%, 36.3% and 31.3% after addition of the high concentration (100 mg/ml) of water extract of Panax ginseng, Panax japonicus and Panax quinquefolium. The contractile response of mesenteric arteries were inhibited by 88.3%, 87.7%, and 70.3% after addition of the high concentration (100 mg/ml) of water extract of Panax ginseng, Panax japonicus and Panax quinquefolium.Conclusions : In conclusion, water extract of genus Panax - induced relaxation in the isolated rat thoracic aorta and mesenteric artery were composed of endothelium - independent relaxation and dose - dependent relaxation.

keywords
genus Panax, 5-Hydroxytryptamine, Phenylephrine, relaxation, genus Panax, 5-Hydroxytryptamine, Phenylephrine, relaxation


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