- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Anti-inflammatory effects of an ethanolic extract from Betula Platyphylla
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.1, pp.184-195
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(2006). Anti-inflammatory effects of an ethanolic extract from Betula Platyphylla. Journal of Korean Medicine, 27(1), 184-195.
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Abstract
Objectives : Betula Platyphylla (BP) is a traditional analgesic, anti-fungal, anti-inflammatory herb used in Chinese medicine. However, no information is available to explain its action. In this study, we investigated the anti-inflammatory effects of BP to elucidate the molecular pharmacological activity in the ethanol extract of BP(BPE).Methods : We performed MTS assay in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages with BPE. Nitrite was measured by Griess assay, prostaglandin E2 (PGE2) by enzyme-linked immunosorbent assay (ELISA) in LPS induced RAW264.7 macrophages with BPE. Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) were determined by Western blot. Activation of nuclear factor-kappaB (NF-κB) was measured by electrophoretic mobility shift assay (EMSA).Results : BPE significantly suppressed production of nitric oxide (NO) and PGE2 in LPS-induced RAW264.7 macrophages in a dose-dependent manner. The maximal inhibition rate of NO and PGE2 production by BPE was ca. 88.8% and 93% at the concentration of 100 ㎍/㎖ (non-cytotoxic concentration), respectively. BPE also decreased iNOS protein and COX-2 protein in LPS-induced RAW264.7 macrophages. EMSA demonstrated that BPE inhibited the DNA binding activity of the NF-κB.Conclusions : These results suggest that BPE inhibits NF-κB-mediated gene expression and downregulates inflammatory mediator production in RAW264.7 macrophages.
- keywords
- Betula Platyphylla, anti-inflammatory effect, Betula Platyphylla, anti-inflammatory effect
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