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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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고지방식이로 유발된 비만 흰쥐의 체지방 및 Leptin과 Neuropeptied-Y(NPY)에 대한 홍삼 조사포닌의 효과

Effect of Crude Saponin of Korea Red Ginsengon High Fat Diet-induced Obese Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2006, v.27 no.3, pp.1-13
한윤정 (경희대학교 동서신의학병원)
김장현 (동국대학교 분당한방병원)
한윤정, & 김장현. (2006). 고지방식이로 유발된 비만 흰쥐의 체지방 및 Leptin과 Neuropeptied-Y(NPY)에 대한 홍삼 조사포닌의 효과. 대한한의학회지, 27(3), 1-13.
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Abstract

Objectives: The purpose of this study is to investigate the anti-obesity effects of Crude Saponin(CS) in Korea Red Ginseng(KRG) on rats fed a high fat(HF) diet. Methods: Male Sprague-Dawley(SD) rats divided into normal diet group and high-fat(HF) diet group. HF diet group became obese by feeding a HF diet over five weeks. Normal diet group were fed on a normal diet. Each CS group of normal diet group and HF diet group was administered CS(200 mg/kg, i.p.) for three weeks, control group of both group was administered normal saline(1㎖/㎏, i.p.) instead of CS. Each group had 5 rats. Results: After administration of CS, the body weight, food consumption, adipose tissues, and expression of appetite peptides such as Leptin and neuropeptide-Y(NPY) were investigated in HF diet group as well as normal diet group. Administration of CS reduced body weight, food intake, and fat content in HF diet group and normal diet group. After CS administration, the NPY expression and Leptin were reduced in HF diet group. Conclusion: Our results suggest that CS may be useful in the treatment of obesity, especially type of qixu(氣虛)

keywords
Crude saponin of Korea Red Ginseng, Neuropeptide-Y, Leptin, anti-obesity, Crude saponin of Korea Red Ginseng, Neuropeptide-Y, Leptin, anti-obesity


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